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DIOSED-C tablets

DIOSED-C tablets. With vitamin C. Medical Background. Veins of Lower Limb: These are divided into 3 groups: Deep Veins Superficial Veins Perforators. Medical Background. Deep Veins: Linear Beneath the deep fascia accompanying Arteries.

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DIOSED-C tablets

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  1. DIOSED-C tablets With vitamin C

  2. Medical Background Veins of Lower Limb:These are divided into 3 groups: • Deep Veins • Superficial Veins • Perforators

  3. Medical Background • Deep Veins: • Linear Beneath the deep fascia accompanying Arteries. • These veins drain the structures deep to the deep fascia and receive blood from the superficial veins through the perforating veins. • They include Planter, Ant.Tibial, Post.Tibial, Popliteal and Femoral veins.

  4. Medical Background 2. Superficial Veins: • Lie Superficial to the deep fascia (i.e. in the S.C tissues). • Drain the skin and S.C tissues of L.L except the skin of lower 1/3 of leg (ulcer bearing area) which drained by Ankle perforators which pierce the deep fascia to end directly in the deep veins.

  5. Medical Background Superficial Veins include: Long (Great) Saphenous vein: • Begins on the dorsum of the foot as a continuation of medial end of dorsal venous arch of foot. • It ascends in front of medial malleolus,medial aspect of leg. • It ends by piercing the cribiform fascia to join the femoral vein at the sepheno femoral junction.(4 cm below & lateral to the tubercle). Communicators: • The long and the short Saphenous veins are connected to each other many variable unfixed communicators.

  6. Medical Background Short (Lesser) Saphenous vein: • Begin on the dorsum of the foot as a continuation of lateral of dorsal venous arch of the foot. • It passes below & behind the lateral malleolus to reach the back of leg to ascend the center of the calf. • Commonly it ends in the popliteal fossa by joining the popliteal vein (Sapheno-popliteal junction).

  7. Medical Background 3.Perforators: Theseveins perforate the deep fascia to connect the deep & the superficial systems.This may be: • Indirect Perforators:Pass from: superficial veins muscular veins deep veins. • Direct Perforators:Pass from superficial veins deep veins.

  8. Diosed-C : Usages: • Varicose veins. • Dysfunctional uterine bleeding. • Hemorrhoid.

  9. DIOSED-C: Composition: • Diosmin is of plant origin, flavonoid fraction. • Diosmin is a 7-rutinoside 3,5,7-trhydroxy-4-methoxyflavone. • Flavonoid are known to reduce reactive oxygen radicals released by (PMNs)-polymorph-nuclear nutrophils in vitro. • Rutin is a greenish yellow micro crystalline powder obtained from black wheat “fago pyrum esculentum”. • Diosmin used similar to rutin in the treatment of venous disorders.

  10. DIOSED-C: Pharmacokinetics: • Diosmin is rapidly absorbed after oral administration. • Diosmin has rapid onset & long duration of action. • Diosmin has minimal transplacental & breast milk passage. • Diosmin has long plasma elimination half-life ranging from 26 to 43 hours. • Diosmin is eliminated as minor metabolites in urine mainly as Glucoronic acid conjugate.

  11. DIOSED-C: Mechanism of action: • Diosmin has vaso constrictive effect by local inhibition of COMT (Catechol-o-methyltransferase) enzyme activity. • Diosmin enhances the sympathetic activity by increasing nor-adrenaline levels in the synaptic clefts of the vascular wall.

  12. DIOSED-C: Mechanism of action: 3.Diosmin reduces the micro vascular high permeability. 4.It Improves cutaneous micro-circulation as it: • Normalizes capillary resistance and permeability. • Inhibits the release of the main pericapillary mediators of inflammation. These described effects on skin microcirculation contribute to a better peri-ulcer nutrition.

  13. DIOSED-C: Mechanism of action: 5.Diosmin has the ability to scavenge active oxygen radicals. 6.Diosmin inhibits (PGE2) synthesis,(PGF2α) and thromboxane B2. 7.Diosmin decrease the R.B.C aggregation which can induce a decrease of blood flow resistance and a reduction in stasis. 8.Diosmin reduces the protein concentration in the intestinal tissues.

  14. Diosmin: • significantly increases venous tone by improving venous wall nor-adrenaline activity. • Veins recover 70% of their maximal contractibility with Diosmin. • Whereas it drops to 40% in controls.

  15. Diosmin: • Diosmin significantly improves the leg ulcer healing process.

  16. Diosed-C • Diosed-C shows an effective and rapid relief of signs and symptoms in acute and chronic Hemorrhoids. • Diosed-C is highly effective as a basic treatment of Hemorrhoids even when complicated.

  17. Diosed-C • Diosed-C is an effective treatment for CVI from early phase to its complications. • Diosed-C has an excellent efficacy on the disappearance of all CVI symptoms.

  18. Diosed-C • Diosed-C is the unique combinationthat allows healthy venous tone. InGynecologyPhlebologyProctology

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