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MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY ACTH, MSHs etc

MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY ACTH, MSHs etc. 1. ACTH, MSH etc. 2. Structural relationships between ACTH, MSH etc. Biosynthesis 3. Opioid peptides 4. Biochemical mode of action of ACTH and MSH; role of MSHs in man (appetite control) 5. Structure-function relationships.

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MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY ACTH, MSHs etc

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  1. MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY ACTH, MSHs etc 1. ACTH, MSH etc. 2. Structural relationships between ACTH, MSH etc. Biosynthesis 3. Opioid peptides 4. Biochemical mode of action of ACTH and MSH; role of MSHs in man (appetite control) 5. Structure-function relationships

  2. Sequence alignment of ACTH-related peptides

  3. Preproopiocortin (Prepro-opiomelanocortin; POMC)

  4. Prohormone converting enzymes Subtilisin-like serine proteases: Cleave after sequence containing two basic amino acids (Lys-Lys, Lys-Arg, Arg-Lys, Arg-Arg) Mutation of PC1 gene gives defects in proinsulin, POMC and LHRH precursor processing Mutation of PC2 gene gives defects in proinsulin, proglucagon and prosomatostatin processing Carboxypeptidases (CPD, CPE and ?CPM) areneeded to complete processing. Missense mutation of CPE gives fat/fat mouse - due to incomplete proinsulin conversion

  5. ENKEPHALINS Met-enkephalin Tyr-Gly-Gly-Phe-Met Leu-enkephalin Tyr-Gly-Gly-Phe-Leu

  6. Preproenkephalins Preproenkephalin A Preproenkephalin B

  7. Actions of MSH in humans 1. Skin darkening and antiinflammatory effects in response to UV light (MC1R) 2. Regulates feeding/appetite. Interacts with leptin and other factors. MC4R in hypothalamus. MC4R mutations can lead to obesity in mice and man 3. Antiinflammatory effects on various cells of immune system. Decreases cytokine production by various immune system cells (esp in brain). Inhibits NF-kB activation (MC1R, MC3R, MC5R) 4. Possible actions on exocrine glands (MC5R) 5. Regulates penile erection and sexual behaviour (MC4R)

  8. MELANIN CONCENTRATING HORMONE (MCH) (From Pissios & Maratos-Flier) Mammalian Salmon

  9. Melanotropic activities of some analogues of a-MSH

  10. Corticotropic activities of some analogues of ACTH

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