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No Significant Difference in Clinical Outcomes of Carvedilol Doses in Heart Failure Patients

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This study evaluates the clinical outcomes of patients with chronic stable heart failure receiving carvedilol at varying daily doses (2.5 mg, 5 mg, and 20 mg) over a mean follow-up of 3 years. The findings indicate no significant differences in death or hospitalization rates among the groups, with all-cause mortality and hospitalizations for cardiovascular diseases remaining statistically non-significant. The study highlights the need for further research due to its underpowered design to detect differences in important clinical outcomes.

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No Significant Difference in Clinical Outcomes of Carvedilol Doses in Heart Failure Patients

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  1. J-CHF Death or hospitalization: 22.9% of 2.5 mg, 19.0 % of 5 mg, and 21.2% of 20 mg group (p = 0.61 for 2.5 vs. 5 mg, p = 0.99 for 2.5 vs. 20 mg) All-cause deaths (n): 9, 7, 8 (p = NS), respectively Hospitalization for cardiovascular diseases (n): 8, 10, 5 (p = NS), respectively Hospitalization for heart failure (n): 21, 14, 18 (p = NS), respectively Trial design: Patients with chronic stable heart failure were randomized to carvedilol 2.5 mg daily (n = 119), 5 mg daily (n = 121), or 20 mg daily (n = 120). Mean follow-up, 3 years. Results (p = NS) (p = NS) Conclusions • Among patients with chronic stable heart failure, there was no apparent difference in clinical outcomes at a mean of 3 years of follow-up among three doses of carvedilol • This study was significantly underpowered to detect a difference in important clinical outcomes Death or hospitalization (%) Number for all-cause deaths (n) 2.5 mg 5 mg 20 mg Presented by Dr. Mosatsugu Hori at AHA 2009

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