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In the name of god

In the name of god. Herpes simplex. Herpes simplex virus HSV 1 HSV 2 HSV 1 : cause a majority of cases of oral and pharyngeal infection, meningoencephalitis and dermatitis above the waist HSV 2 : is implicated in most genital infections .

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In the name of god

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  1. In the name of god

  2. Herpes simplex • Herpes simplex virus HSV1 HSV2 • HSV1: cause a majority of cases of oral and pharyngeal infection, meningoencephalitis and dermatitis above the waist • HSV2: is implicated in most genital infections

  3. Primary herpes simplex virus infections • Primary HSV infection occurs in patient who do not have immunity resulting from previous contact with the virus • The majority of oral HSV infections is caused by HSV1, but primary oral HSV infections may also occur chiefly result of oral-genital contact • Infection of the finger (herpetic whitlows) of health professionals may occur during treatment of infected patients.

  4. During the first 6months:are protected Newborn After 6 month of age : incidence of primary HSV1infectionincreases Between 2 and 3 years of age: incidence of primary HSV1 infection reaches a peak

  5. Incidence of primary HSV2 infection dose not increase until the age when sexual activity begins The incidence of primary herpes infection has been shown to vary according to socioeconomic group

  6. Clinical manifestations • History of generalized prodromal symptoms that precede the local lesions bye 1 or 2 days. • These generalized symptoms include fever, headache, malaise, nausea, and vomiting. • A negative past history of recurrent herpes labialis. • A positive history of direct intimate contact whit a patient whit primary or recurrent herpes

  7. 1 or 2 days aftergeneralized symptoms small vesicles (thin walled-inflammatory base) rupture shallow round discrete ulcers • An important diagnostic criterion in this disease is the appearance of generalized acute marginal gingivitis • Primary HSV in healthy children is self-limiting disease.

  8. Laboratory diagnosis • Cytology :giant cell. Syncytium. Ballooning degeneration • HSV isolation: is the most positive method of identification and sensitivity 100% • Antibody titers:antibody to HSV will begin to appear in a week and reach a peak in 3 weeks

  9. treatment • Acyclovir : inhibits DNA replication in HSV infected cell • Valacyclovir & famciclovir : effective treatment with fewer doses. • Supportive treatment:1)aspirin or acetaminophen for fever 2) fluids to maintain proper hydration and electrolyte balance.

  10. Recurrent herpes simplex virus • Recurrent herpes is a reactivation of virus that remains latent in nerve tissue. • Several mechanisms for reactivation of latent HSV: low serum IgA, cell mediated immunity salivary antiherpes activity, ADCC and interleukin2

  11. Clinical manifestations • Tingling or burning with edema a cluster of small vesicle(1-2 cm – 1 to 3 mm in diameter)

  12. Diagnosis • Giant cell • Ballooning degeneration

  13. Treatment • Acyclovir: suppress the formation and shorten the healing time of new recurrent lesions. • Famciclovir: decrease the rate of HSV latency

  14. Good luck

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