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Implantable Drug Delivery Systems are designed to release therapeutic agents over extended periods, ranging from weeks to years.<br>
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Understanding Implantable Drug Delivery Systems Implantable Drug Delivery Systems are designed to release therapeutic agents over extended periods, ranging from weeks to years. They function as internal repositories that provide precise doses directly at the site of action or into systemic circulation. This method contrasts sharply with traditional oral medications, which often suffer from erratic absorption and limited bioavailability.
2. Key Benefits of IDDS: Targeted Action: Drugs can be delivered directly to the site of interest, reducing systemic exposure. Improved Patient Compliance: Reduced frequency of administration leads to better adherence to treatment regimens. Sustained Release: These systems can maintain therapeutic drug levels over time, avoiding peaks and troughs associated with conventional dosing methods.
3. Manufacturing Challenges In case of implantable devices, one has to select biomaterials that are biocompatible and biodegradable. The major challenge is to provide drug release with safety and biocompatibility with human tissues. Usual candidates are PLGA and PDMS, but they are under challenge due to variable degradation rates and unsatisfactory mechanical properties.
4. Solutions to Manufacturing Challenges Research into new biomaterials that offer improved biocompatibility and controlled degradation rates is ongoing. For instance, incorporating nanoparticles into polymer matrices can enhance drug loading capacity and modify release kinetics.
Read More: https://euroinsightscare.com/innovations-in-implantable-drug-delivery-systems/