Biological and Bioorganic Chemistry
Meet the Lecturer Dr. Denis Svechkarev, PhD in Organic Chemistry Associate Professor, Department of Organic Chemistry, Faculty of Chemistry, Kharkov V. N. Karazin National University Senior Researcher, Department of Physical Organic Chemistry, Institute for Chemistry at Kharkov V. N. Karazin National University
Simple way to success Respect the subject, as well as those who are working to improve your knowledge. Attend the lectures – this is your main source of knowledge. Take good, concise lecture notes. Use of cell phones in the lecture room or lab is strictly prohibited! If you need to make a call – wait until the end of the class. If it’s really urgent – leave the room, make a call and then come back. I will not tolerate with any demonstration of disrespect or any violation of discipline!
Some useful material niichem.univer.kharkov.ua/physorg chemlaba.wordpress.com
What shall we do? Introduction to organic and biological chemistry. Classes and nomenclature of organic compounds. Saturated and unsaturated hydrocarbons. SR and AdE reactions. Feb 14 Aromatic hydrocarbons. Orientation in the aromatic ring. Halogen derivatives of hydrocarbons. SN reacions. Alcohols, ethers. Polyhydric alcohols. Feb 21 Feb 28 Carbonyl compounds – aldehydes and ketones. Carbohydrates. Carboxylic acids and their derivatives: amides, nitriles, anhydrides. Esters, fats. Mar 7 Amines, aminoacids, peptides. Heterocyclic compounds and their biological activity. Mar 14
Power of life and vitalism AgNCO + NH4Cl → (NH2)2CO + AgCl
Theory of chemical structure Alexander Butlerov Eminent Russian chemist, one of the founders of the theory of chemical structure. First scientist to introduce double bonds in structural formulae.
Classification of organic compounds • Halogen derivatives • Oxygen-containing: • Alcohols & ethers • Aldehydes & ketones • Carboxylic acids & esters • Nitrogen-containing: • Amines • Nitriles • Mixed: • Aminoacids • Peptides • Nitro compounds • …
Naming alkanes CnH2n+2
Chemical properties of cycloalkanes Small cycles show some particular properties:
Naming alkenes CnH2n
Addition to the double bond – AdE reactions Markovnikov rule
Naming and properties of alkynes CnH2n-2
Isomerism of alkynes • triple bond position in alkyne molecule • carbon skeleton branching • interclass isomerism: • alkadienes • cycloalkenes