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Understanding Lipids: Functions, Types, and Metabolism

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This lecture explores the diverse world of lipids, covering essential topics such as triacylglycerols, fatty acids, and unsaturated fatty acids, including their nomenclature and differences between cis and trans fats. We will delve into phospholipids, sphingolipids, glycolipids, and the implications of lysosomal storage disorders. The lecture highlights the functional roles of lipids in hormones, vision, immunity, and bile production. Additionally, we will discuss lipid metabolism, including the transport and mobilization of fats, beta-oxidation, and the unique characteristics of amphipathic lipids in membrane formation.

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Understanding Lipids: Functions, Types, and Metabolism

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Presentation Transcript

  1. Lecture 20 QUESTIONS? Text 37607 Msg: 118916 Question QUESTIONS? Gotohttp://pollev.com/ucibio Enter question

  2. What are lipids

  3. Triacylglycerols

  4. Fatty acids

  5. Unsaturated fatty acids - nomenclature

  6. Triacylglycerols

  7. Heading

  8. Unsaturated fatty acids – cisVS trans

  9. Trans fats

  10. Phospholipids

  11. Sphingosine & Sphingolipids

  12. Glycolipids

  13. Lysosomal storage disorders

  14. Lysosomal storage disorders

  15. Ether lipids

  16. Steroid rings

  17. Functions of lipids: Hormones

  18. Functions of lipids: Sight!

  19. Functions of lipids

  20. Functions of lipids: Bile(?)

  21. Lipid-derived antibiotics

  22. Functions of lipids: Immunity

  23. Amphipathic lipids form…

  24. …membranes

  25. Membranes

  26. Lipid properties = Membrane properties

  27. Lipidomics!

  28. Lipids as energy Glycogen store = 1 day Lipid stores = Weeks! No net conversion of Fats  Glc Brain needs Glc… or does it?

  29. Transporting lipids

  30. Mobilizing fats

  31. Different tissues = different metabolic roles

  32. Using Glycerol

  33. Breaking down fatty acids Conceptually simple 1. Activate 2. Transport 3. Beta-oxidation

  34. Activating fatty acids

  35. Compartments – again!

  36. b-oxidation: Overview

  37. b-oxidation

  38. b-oxidation

  39. b-oxidation

  40. Modularity in biochem!

  41. Odd chains

  42. Mono unsaturation

  43. Poly unsaturation

  44. Poly unsaturation

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