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This presentation focuses on the pharmacokinetic and pharmacodynamic modeling of vitellogenin (Vg) formation using indirect-response models. It explores the dynamics of the EE2-estrogen receptor complex and the influence of kDNA parameters such as kon and koff. The session includes detailed profiles of Vg and EE2 concentration over time following EE2 injection, alongside a discussion of excretion pathways and the impacts on biomarker dosimetry. Key methodologies and findings will be illustrated to enhance understanding of Vg synthesis and its relevance in chemical dosimetry.

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  1. Stock Slides contains groups, etc. useful in making slides.

  2. Pharmacokinetic-Pharmacodynamic Modeling of Vg Formation Using Indirect-Response Models. EE2-Estrogen Receptor complex kDNA kon EE2 koff   Vg + “transit compartments” Receptor Binding, Nuclear Translocation & Vg Synthesis Biomarker Dosimetry Chemical Dosimetry Pharmacokinetics Pharmacodynamics1 Excretion of Vg 1Xu et. al. (1995). J. Pharmacokinetics and Biopharmaceutics23:163-181.

  3. Vg concentration-time profile after EE2 injection (initial 100 hrs)

  4. Vg, EE2 concentration-time profiles after IA injection of EE2 t½= 132 hrs t½= 30.7 hrs t½= 20.1 hrs

  5. copy of grouped object

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