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Center for Translational Neuroscience Distinguished Speaker Series

Center for Translational Neuroscience Distinguished Speaker Series. Rayford Auditorium, Biomed II Bldg. Tuesday, September 30, 12 noon. “Progressive development of spontaneous seizures in experimental epilepsy” F. Edward Dudek, Ph.D. Professor and Chair Department of Physiology

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Center for Translational Neuroscience Distinguished Speaker Series

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  1. Center for Translational Neuroscience Distinguished Speaker Series Rayford Auditorium, Biomed II Bldg. Tuesday, September 30, 12 noon “Progressive development of spontaneous seizures in experimental epilepsy” F. Edward Dudek, Ph.D. Professor and Chair Department of Physiology University of Utah School of Medicine Salt Lake City, UT

  2. Epilepsy may be a progressive disorder, although progression is likely to be obscured by anticonvulsant treatment in humans with acquired epilepsy. These experiments aimed to test the hypothesis that epileptogenesis is a continuous function of time after injury and continues after the latent period to the first seizure. Using nearly continuous hippocampal recordings with radiotelemetry, electrographic seizure frequency was analyzed quantitatively for 100 days after kainate-induced status epilepticus in adult rats. Seizure frequency progressively increased as a sigmoid function of time. These data support the hypothesis that epileptogensis is a progressive process that continues to develop well beyond the first spontaneous seizure, and suggests that the window for anti-epileptogenic therapeutic regimes aimed at reducing the progressive worsening of the epilepsy extends well beyond the latent period.

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