EE3080 Design and Innovation Project Programme : Electromedical Technologies Coordinator:

1. EE3080 Design and Innovation Project Programme: Electromedical Technologies Coordinator: Asst. Prof. Justin Dauwels jdauwels@ntu.edu.sg School of Electrical and Electronic Engineering Nanyang Technological University

2. What is Biomedical Engineering? Biomedical engineering is a multiple discipline and high technology area. It is to provide solutions for health care industries and services. ELECTROMEDICAL technologies: electrical engineering applied to healthcare

3. Electrical Engineers Play a Key Role in Health Care Industries

4. Septum Pacemaker Papillary muscle 750 mm 4-shank probe Electrical Engineers Play an Key Role in Health Care Industries and Services Circuits and electronics Measurement and instrumentation

5. Brain Mapping from EEG ECG Electrical Engineers Play an Key Role in Health Care Industries and Services Information and signal processing Medical imaging and image processing

6. Electrical Engineers Play an Key Role in Health Care Industries and Services Modelling and control Telemedicine

7. Biomedical Engineering is Exciting • It is important:Health Caring and Life Saving • It is profound and challenging: • Nobel Prizes in Medicine in 1979, for the development of Computed Tomography (CT) and in 2003 for the development of Magnetic Resonance Imaging (MRI). • It is High Tech =

8. Health Care Industry is Robust and Resilient in the Economic Crisis Performance of Different Sectors of NYSE (2007 – 2013)

9. Where do Biomedical Engineers work ? Research Institutions Institute of Bioengineering and Nanotechnology Bioinformatics Institute Institute of Molecular and Cell Biology Defence Medical Research Institute Bioprocessing Technology Centre Laboratories for Information Technology Johns Hopkins Singapore Pte Ltd Hospitals SGH NUH NCC SNEC NHC NNI SINGAPORE Companies Baxter Becton Dickinson Siemens Medical Instruments Medtronic GE Medical Boston Scientific GlaxoSmithKline MDS Analytical Technologies Perkin Elmer Academic Institutions/Government Boards NTU Universities Polytechnics

10. Wearable Respiratory Monitoring POC Sensor Platform Wireless Sensing Microscope-on-Chip Spectroscopy-on-Chip Opto- & Nano- Fluidic Chips Elderly Home Monitoring Inspired by Clinical Needs Reputed for Impactful Research Lab-on-Chip nanochannel microchannel Telemedicine Neuro-Device Implants Quantum Dots Probe Brain Disorder Diagnostic Photo-Thermal Imaging DCE Imaging • 25 Active EEE Faculty Members Research at School of EEE on Electromedical Technologies

11. Distributed Diagnosis & Home Healthcare (D2H2) Non-Contact Vital Sign Biosensors Tele-Rehabilitation Intelligent Controller Clinics and Hospitals Wherever the patient is.. Other Specialist & Clinicians Personal Health Information Management System (PHIMS) Internet Home Healthcare Monitoring or Diagnostic System Emergency Room Handheld Devices Wearable System Primary Care Provider Smart Homecare Monitoring Prof. Tjin Swee Chuan, et al

12. Bio-Imaging & Signal Processing DCE Imaging of Tumor Microcirculation Diagnosis/Treatment of Brain Disorders Nasopharyngeal Cancer Diagnosis with optical Coherence tomography • The use of dynamic contrast-enhanced MR imaging (DCE MRI) and dynamic contrast-enhanced CT imaging (DCE CT) as a biomarker for anti-angiogenesis therapy • Neuro-electric Engineering for Curing Brain Disorders • Nasopharyngeal Cancer Diagnosis with Optical Coherence Tomography • Fluorescence Life-time Imaging for Medical Diagnosis of Cancerous Tissue • Development of Photo thermal Imaging system for imaging sub-cellular organelles • Processing and Classification of Heart Rate Variability Signals

13. nanochannel microchannel Bio-Nano Technology and Devices Micro-fluidic Chips and Devices Lab on Chip (Nano-Droplet & Bubble Formation) Formation of hydrogel plug Transformation from plug to spherical droplet Microscope on Chip (3D Ultrasound, CMOS Imager) Point-of-Care Biosensor Platform Outlet Inlet + nanochannel microchannel Outlet Integrated LSPR Chip Nanopatternfabrication CMOS Imager Inlet Outlet Optofluidic channels LSPR simulation • Multilayer micro-fluidic chip (to form single tumor spheroid), device (for neuron culture) • Lab on Chip (Nano-Droplet and bubble formation) – to mimic blood flow in artery • On-chip total internal reflection (TIR) microscope • Point-of-Care Biosensor platform for screening/diagnosis of cancer & infectious diseases • Microscope on Chip: 3D ultrasound system, CMOS imager near-field System

14. Major Laboratory Facilities • Cell Culture Room • Research inverted microscope, Incubator, Centrifuge, Water bath, Ultrapure water system, Ultralow (-80o) freezer, • Cryogenic tank • Biochemical Room • Chemical cabinet, Chemical benches, Chemical hood, Universal laser cutting system • Dark Room • Optical tables, Lasers, Supercontinuumlight source • Other Equipments • Ultrasound X-Y-Z scanning system, Sonix RP ultrasound system, Medelec Profile EEG system, Biopac, NORAXON EMG system, Desktop MRI scanning system.

15. Thanks! Join this programme to become a leader in healthcare innovation … … and improve the quality of life of many patients! We welcome your ideas! Professors will soon upload projects.

16. EE3080 Design and Innovation Project Programme: Electromedical Technologies Coordinator: Asst. Prof. Justin Dauwels jdauwels@ntu.edu.sg School of Electrical and Electronic Engineering Nanyang Technological University