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In managing metastatic colorectal cancer (mCRC), particularly in cases with liver metastases, a tailored treatment strategy derived from comprehensive patient assessment is pivotal. Approximately 10% of patients are deemed upfront resectable, allowing for potentially curative surgery. In contrast, around 60% are categorized as unresectable, with treatment focused on prolonging survival and maintaining quality of life. Chemotherapy remains a critical component in the management of these patients, as outlined in the modified framework by Nordlinger et al. in Ann Oncol 2009.
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