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A girl with persistent leg pain for 2 weeks, localized in the same area, requiring analgesics and causing weakness at night. Suspected osteosarcoma. Diagnostic tests, staging, and treatment discussed. |
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specialities Traumatology Orthopedics Rheumatology Immunology Infectology Hematology Oncology General pediatrics
questions Which leg? Exactly where? Since when? Did she have it earlier? Any trauma? Also painful in the night? Does she need any medication? Immobility? Pain in other localisation? Earlier disease? Chronic disease? Skin symptoms? Fever, diarrhoea?
examination Physical examination Blood CBC, CRP, We, smear PCT, CK, LDH serology: Staph., Strepto., Salmonella, Yersinia, Campylobacter, E.coli, Borellia, tbc AI: RF, ANA, ANCA, SCAT Radiology X-ray US MR CT Bone scintigraphy
No trauma • No feverinthelastperiode • Intheanamnesis no severedisease • Leftkneepainful – alwaysonthesamelocalisation • Afterphysicalactivitiypainincreases • Sometimessheweaksupduringthenightbecause of thepain • Sometimessheneedsanalgetics • 2 weeksduration, alwaysonthesameplacelocalisedbone-pain • • X-ray 14 years old girlleg pain
2 weeksduration, alwaysonthesameplacelocalisedbone-pain X-ray suspectedmalignancy openbiopsy dg: osteosarcoma 14 years old girlleg pain
dg: osteosarcoma Staging: local MRI bone scintigraphy chest CT/MRI Therapy: neoadjuvant chemo operation adjuvant chemo 14 years old girlleg pain
1,0 non-metastatic ,8 ,6 ,4 metastatic ,2 Survival probability 0,0 0 20 40 60 80 100 120 140 160 180 Follow-up (months) OSC over-all survival