1 / 8

Modeling of Acute R esistance to the HER2 Inhibitor , L apatinib , in Breast C ancer C ells

Modeling of Acute R esistance to the HER2 Inhibitor , L apatinib , in Breast C ancer C ells. Marc Fink & Yan Liu Student Project Proposal Computational Cell Biology 2012. Motivation. Observation during experiments : Lapatinib kills most cells but some of them can survive.

gail
Télécharger la présentation

Modeling of Acute R esistance to the HER2 Inhibitor , L apatinib , in Breast C ancer C ells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Modeling of Acute Resistance to the HER2 Inhibitor, Lapatinib, in Breast Cancer Cells Marc Fink & Yan Liu Student Project Proposal Computational Cell Biology 2012

  2. Motivation Observation during experiments: Lapatinibkills most cellsbut some of them can survive. Hypothesis: Secondary receptor pathways leads to cell survival. Goal: Regenerate the experimental results with mathematical model and find out the factors which influence the percentage of cell survival

  3. Mechanistic (process) diagrams Lapatinib HER2 PI3K PDK1 p Protein Translation AKT (PKB) p ER FoxO p FoxO p 14-3-3 Translocation Translocation Transcription FoxO FoxO Apoptotic genes

  4. Mechanistic (process) diagrams Lapatinib Lapatinib HER2 PI3K PDK1 p Protein Translation AKT (PKB) p ER FoxO p FoxO p 14-3-3 Translocation Translocation Transcription FoxO FoxO Apoptotic genes FoxO FoxO Survival genes

  5. Mechanistic (process) diagrams Death Lapatinib ?????? HER2 Survival PI3K PDK1 p Protein Translation AKT (PKB) p ER FoxO p FoxO p 14-3-3 Translocation Translocation Transcription FoxO FoxO Apoptotic genes FoxO FoxO Survival genes

  6. Kinetic model equations [Park, Schneider, Haugh, 2003]

  7. Working schedule • Finish and modify the mechanistic diagrams • Build up model in Vcell or Matlab • Compare simulation results with experimental results • Analyze the model and estimate/tune parameters • Consider stochastic model, if necessary • Analyze the results • Documentation of the project

  8. Questions and Suggestions?

More Related