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MARK BARTLETT, PHD

MARK BARTLETT, PHD. Vice President, Global Research and Development Pharmanex. DIE YOUNG. ..as late in life as possible. Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business opportunity through PRODUCT INNOVATION.

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MARK BARTLETT, PHD

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  1. MARK BARTLETT, PHD Vice President, Global Research and Development Pharmanex

  2. DIE YOUNG ..as late in life as possible

  3. Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business opportunity through PRODUCT INNOVATION

  4. Our anti-aging product strategyis to leverage LEADING EDGE SCIENCE to further understand the aging process. • Science in product development • Discovery process • Development process • Scientific assets • Multiple unique tools to discover and develop anti-aging products with meaningful benefits

  5. AGELOC GENE TECHNOLOGY GENE EXPRESSION IN YOUNG TISSUE GENE EXPRESSION IN OLD TISSUE OLD GENE EXPRESSIONAFTER AGELOC Gene Expression Scale Low Expression High Expression FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a pre-clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column 1.1 1Transcriptional Biomarkers of Mitochondrial Aging and Modulation by CordycepsSinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.

  6. Our Science, Your guarantee • Quality • Innovation • Safety • Substantiated claims 6S Quality Process Selection; Sourcing; Standardization; Safety; Structure; Substantiation

  7. ANTI-AGING PRODUCT DEVELOPMENT PROCESS 6S process ageLOC science TOOLKIT

  8. R&D ENGINE - PROVO INNOVATION CENTER

  9. R&D ENGINE CHINA INNOVATION PARK

  10. NEW ANTI-AGING AGELOC TOOLS LifeGen • Patented technologies to study anti-aging interventions through gene expression science • Acquired November 2011 NOX Technologies • Patented anti-aging technology • Incorporated in ageLOC Transformation and Galvanic Gels • Acquired November 2012

  11. Healthy Aging Nutrition Science Antioxidant Science GeneScience ???

  12. AGELOC GAMMA: WEIGHT MANAGEMENT SYSTEM • AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene expression science • ageLOC Gamma helps you look slimmer and healthier in 90 days when used in conjunction with a healthy diet and exercise Simple Eating & Lifestyle Plan Advanced ageLOC Products

  13. AGELOC GAMMA: INFLUENCING WEIGHT • Key Tissues • There are key tissues that address critical areas of weight loss through gene expression. ageLOC Gamma will focus on these key tissues

  14. AGELOC GAMMA

  15. AGELOC GAMMA: STUDIES • LifeGen (gene expression science) • Gene array analysis to elucidate YGCs • Clinical Studies • Open label study (ongoing) • Larger trial (starting in 2013)

  16. GAMMA SYSTEM Incorporating ageLOC science and clinically demonstrated ingredients 18

  17. AGELOC GAMMA REPRESENTS A MAJOR INNOVATION WITH GENE EXPRESSION SCIENCE

  18. S3: SCANNER UPGRADECOMING SUMMER 2013 • 25% smaller • Wireless • Battery operated

  19. FUTURE PIPELINE INNOVATIVE ageLOC SKIN CARE and NUTRITION

  20. AGELOC INNOVATION PATTERN 2010 2013 2020

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