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Understanding the Action Model of LMP1-Derived DN on LMP1 Signaling Pathways

This article examines the action model of LMP1-derived dominant negative (DN) mutants on LMP1 signaling mechanisms. Specifically, it explores the role of LMP1 cytoplasmic tail (LMP1-CT) and its interactions with signaling molecules like TRAF and TRADD. The findings contribute to our understanding of LMP1's role in oncogenic signaling and potential therapeutic targets in virus-associated cancers, as discussed by Adriaenssens et al. in their 2004 study published in Oncogene.

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Understanding the Action Model of LMP1-Derived DN on LMP1 Signaling Pathways

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  1. Model of action of LMP1-derived DN on LMP1 signaling LMP1-CT GFP SIGNAL SIGNAL RIP (Adriaenssens et al., Oncogene 2004) LMP1 TRAF TRADD TRAF

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