1 / 22

Virus-Induced Immunopathology

Cell mediated immunopathology. Contact between CTL (CD8 ) and targetTCR recognizes cognate peptide presented by MHC IActivation of CTL; release of membrane granules with perforin and granzymePerforin: Pore formation in target cells resuting in cytolysisGranzyme B: induction of apoptosisRelease

garin
Télécharger la présentation

Virus-Induced Immunopathology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Virus-Induced Immunopathology Cell mediated Immunopathology Antibody-mediated Immunopathology Virus-initiated Immunopathology

    2. Cell mediated immunopathology Contact between CTL (CD8+) and target TCR recognizes cognate peptide presented by MHC I Activation of CTL; release of membrane granules with perforin and granzyme Perforin: Pore formation in target cells resuting in cytolysis Granzyme B: induction of apoptosis Release of Inflammatory cytokines (TNF-a, IFN-g, ILs) CD4+ T cells can enhance CD8-mediated immunopathology NK Cell Non-specific of non-self ADCC

More Related