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NMP22® BladderChek® Test

NMP22® BladderChek® Test. Case Studies. Value of a “False Positive” Test Result: Case Study #2. Diagnosis : 68 year old male non-smoker Presenting symptom: Hematuria Cystoscopy: Benign / Suspicious Cytology: Atypical / Suspicious NMP22 BladderChek: Positive Pathology:  TCC T2aG3 .

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NMP22® BladderChek® Test

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  1. NMP22® BladderChek® Test Case Studies

  2. Value of a “False Positive” Test Result:Case Study #2 Diagnosis: • 68 year old male non-smoker • Presenting symptom: Hematuria • Cystoscopy: Benign / Suspicious • Cytology: Atypical / Suspicious • NMP22 BladderChek: Positive • Pathology:  TCCT2aG3 1,331 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 293:810-816 (2005) Data on file at Matritech

  3. Value of a “False Positive” Test Result:Case Study #3 Diagnosis: • 68 year old male with H/O smoking • Presenting symptom: Hematuria • Cystoscopy: No abnormality • Cytology: Malignant Cells • NMP22 BladderChek: Positive • Upper tract imaging T2G2 Ca of ureter • Nephroureterectomy 1,331 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 293:810-816 (2005) Data on file at Matritech

  4. Value of a “False Positive” Test Result:Case Study #1 • Monitoring: • 80 yr. old male • 1993 Initial diagnosis: TCC • Immunotherapy • 2/14/02 • Cystoscopy: tumor / benign • Cytology: Suspicious / Atypical • NMP22 BladderChek: Positive • Pathology: TCC Ta G2 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech

  5. Value of a “False Negative” Test Result:Case Study #1 • Monitoring : • 65 yr old male • 2000 Initial diagnosis T1 • 9/2001 Immunotherapy • 12/2001 • Cystoscopy: tumor-like growth • Cytology: Atypical • NMP22 BladderChek: Negative • Pathology: benign disease / urethritis 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech

  6. Added Value when Cytology is “Uninformative”Case Study #1 • Monitoring: • 77 yr old male • 1997 Initial diagnosis: TCC Ta • Sep 2001 Immunotherapy • Oct 2001 • Cystoscopy: tumor / cis • Cytology: Suspicious • NMP22 BladderChek: Positive • Pathology: TCC T1 G3 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech

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