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Assessment of Research Project on Pastoral Agriculture: Managing Sporidesmin Toxicity in Livestock

This research project examines managing Sporidesmin toxicity in pastoral agriculture, particularly in dairy, beef, and sheep. The study evaluates the impact of breeding for resistance, zinc prophylaxis, and treatment options for Facial Eczema. The protocol involves a Sporidesmin challenge on progeny to measure relevant traits. The results indicate that the DNA resource created is powerful for whole genome selection. Ethical considerations including Refinement, Reduction, and Replacement strategies are discussed, highlighting the benefits for improved animal welfare. The annual risk is minimized through this comprehensive approach.

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Assessment of Research Project on Pastoral Agriculture: Managing Sporidesmin Toxicity in Livestock

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  1. Assessing a research project ~ with reference to the big picture. Grant Shackell, AgResearch “Blue sky to deep water: the reality and the promise” ANZCCART Conference 2008 Auckland NZ

  2. ~ 5,000,000 ~ 35,000,000 Pastoral agriculture ~ 5,000,000

  3. Pithomyces chartarum Sporidesmin

  4. Toxicity GGT GDH

  5. Facial Eczema

  6. Treatment • 3% clinical = 50-95% sub-clinical • no cure • Zn prophylaxis – toxicity • breed for resistance • as increases D/R has to increase

  7. Where is it? 70% of dairy 60% of beef 40% of sheep

  8. Texel (T) ewes SusceptibleorResistant? Finnish Landrace (F) rams h2≈ 0.4 160 Coopworth ewes per ram by AI etc. 3 FxT rams 200 half-sib progeny per ram Sporidesmin challenge Measure FE traits of progeny (serum GGT & GDH + liver injury)

  9. The protocol • 2000 animals challenged • 0.2 - 0.3 mg/kg liveweight • blood sampled weekly • good feed supply • shade • welfare commitment

  10. The results • 60% GGT >70 (71- 1185) • animals with elevated GGT/GDH monitored • 15% clinically affected • placed indoors in shade • 0.5% deaths/euthanasia

  11. The outcome • very powerful DNA resource • augment with natural challenge • whole genome selection (SNPs)

  12. Was it justified? There was some ethical cost • Refinement • Reduction • Replacement • Rationale Benefit is improved animal welfare

  13. AnnualRisk

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