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Exploring Amphiphiles: Enhancing Vesicle Functionality

Dive into the world of amphiphiles to optimize vesicle permeability. Learn about different amphiphile structures and their impact on guest molecule release. Discover innovative approaches for creating versatile vesicle containers.

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Exploring Amphiphiles: Enhancing Vesicle Functionality

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  1. Biomass FundamentalsModules 19: Higher Order Functionality in Biomass:Surface Active Materials A capstone course for BioSUCCEED: BioproductsSustainability: a University Cooperative Center of Excellence in EDucation The USDA Higher Education Challenge Grants program gratefully acknowledged for support

  2. This course would not be possible without support from: USDA Higher Education Challenge (HEC) Grants Program www.csrees.usda.gov/funding/rfas/hep_challenge.html

  3. Article of Interest for Discussion • “Comparison of the Leakage of Carboxyfluorescein from Symmetric and Asymmetric-Acyl Chain Phospatidylcholine Vesicles” – Wiedmann, Timothy S.; Salmon, A.; Perkins, Walter R. Pharm. Res.1993, 10, 147-151. • http://springer.metapress.com/content/jm857702236gu462/fulltext.pdf

  4. Building blocks for containers: amphiphiles Surfactant Tail Surfactant Head Surfactant Monomers Micelle

  5. Structure of a Vesicle • Amphiphiles used to make it • Grossly – bilayer structure versus micelle • Unilamellar sphere (SLV) vs MLV (multilamellar) • Hydrophilic core & bulk • Sandwich is hydrophobic

  6. Vesicles as containers • Modify them by employing amphiphiles that moderate permeability • Use symmetric & asymmetric amphiphiles • Make mixed chain, partial interdigitated bilayer

  7. Symmetric amphiphile (16,16 PC)

  8. Asymmetric amphiphile (20,12 PC) 18 10

  9. DSC profiles for vesicles (multilamellar) Multilamellar dispersions • High sensitivity DSC • 20/hr scan rate • Gel-to-liquid crystalline transitions different • Mean diameters = 22090 nm & 210 85 nm for 16/16 PC & 20/12/ PC, respectively Extruded dispersions 20/12 PC 16/16 PC

  10. Time dependence of guest release • Leakiness originates from gel-to-liquid transitions • Carboxyfluorescein is the guest molecule • In the 16/16 PC (circles), there is more release than 20/12 PC (squares) 42C 48C

  11. Release of guest (carboxyfluorescein) as a function of temperature • In 20/12 PC, there is little correlation between % release and temperature (closed circles) • In 16/16 PC, there is definite dependency on T

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