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Convergence in Science and Medicine: The VIA-CI Project at CSUCI

The VIA-CI Project at California State University Channel Islands exemplifies how convergence of technologies enhances science and medicine education. By addressing limited funding for instrumentation through collaboration with educational partners, the project, supported by a $950,000 Amgen Foundation grant, provides access to state-of-the-art molecular structure determination tools. This initiative fosters innovative research and educational opportunities while promoting collaboration among institutions. The VIA-CI Project serves as a model for a cost-effective approach to advanced scientific education and inter-institutional partnerships.

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Convergence in Science and Medicine: The VIA-CI Project at CSUCI

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  1. How is Convergence Helping Science and Medicine? A case study of the VIA-CI Project

  2. CSUCI Background • CSUCI: former Camarillo State Hospital • 2001, Founding faculty member • Opened for students fall, 2002 • Science building opened fall, 2003 • First freshman class graduated spring, 2007 • Commitment to strong science undergraduate and graduate programs: Biology, Chemistry, Computer Science, Mathematics, and Nursing • Service/ Experiential Learning, International and multicultural perspectives • Fully Accredited, as of 7/19/07

  3. Convergence • “the merging of distinct technologies, industries, or devices into a unified whole,” Merriam Webster

  4. A Case Study in Convergence: The VIA-CI Project • Convergence I: • Limited funding for acquiring instrumentation at CSU Channel Islands • Community colleges and private universities had the same problem • Convergence II: • Modern Instrumentation with Auto-samplers • Virtual Conferencing/ Remote Desktop • Virtual Instrumentation Access at CSU Channel Islands (VIA-CI Project)

  5. Amgen Foundation Grant • $950,000 to the CSU Channel Islands Foundation from Amgen Foundation • Purchase of modern instrumentation • Installation of Amgen donated equipment • Remote operation by Educational Partners

  6. Why Molecular Structure Determination? • Drugs typically fall into two categories: • protein therapeutics (Amgen’s Epogen) • small synthetic molecules (Aspirin, Taxol) • Maximize favorable (binding) interactions between small molecules and cellular receptors (proteins) • Shape of protein pocket • Shape of drug and how shape influences binding affinity

  7. Gleevec Story: Structure-Based Drug Design • Novartis: new drug development for Chronic Myeloid Leukemia • Chromosomal aberration causes abnormal protein to be synthesized by cancer cells • Weak and non-differentiating drug prototype • Structure of drug modified so that it had a good “lock and key” fit with the abnormal protein

  8. Remotely Operable, Molecular Structure Facility • X-ray Diffraction • NMR • GCMS

  9. Westmont College California Lutheran Moorpark College College of the Canyons Ventura College Pierce College Oxnard College CSU Channel Islands Pepperdine University Educational Partners

  10. Non-Convergence: Multiple Site Instrumentation >$10 Million to Implement

  11. Convergence: the VIA-CI Concept $1 Million to Implement VIA-CI

  12. Educational Partner sites secure tunnel firewall and switch VIA-CI Server NMR GC-MS How VIA-CI Works

  13. What do the Partners See?

  14. Challenges • Developing a Perspective of Value • Different needs of 2 year vs. 4 year Educational Partners • Computer infrastructure and scheduling • Faculty development/ training • Long-term funding for sustaining and expanding the VIA-CI Project • Atomic Force Microscope ($65K)

  15. Opportunities • Dissemination of the VIA-CI approach • Recruitment of students • Collaboration between campuses • Sharing of best practices • Grant opportunities for inter-institutional collaborations/ research

  16. Conclusion • Innovative approach to collaboration among institutions of higher education • Model for a cost-effective approach to facilitating an advanced scientific and technological education

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