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PATHOPHYSIOLOGY OF TISSUE GROWTH Professor Yu.I. Bondarenko

PATHOPHYSIOLOGY OF TISSUE GROWTH Professor Yu.I. Bondarenko. PLAN. 1 . Tumor , it pathophysiological characteristic 2. Е tiology of tumor 3. Conception of oncogene 4. Stages of cancerogenesis. Definition of tumor.

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PATHOPHYSIOLOGY OF TISSUE GROWTH Professor Yu.I. Bondarenko

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  1. PATHOPHYSIOLOGY OF TISSUE GROWTHProfessor Yu.I. Bondarenko

  2. PLAN • 1.Tumor, it pathophysiologicalcharacteristic • 2. Еtiology oftumor • 3. Conception of oncogene • 4. Stages of cancerogenesis

  3. Definition of tumor • Tumor− typical pathological processin appearanceof tissue growth upischaracterized with potentialunlimitedgrowth, growth unregulationand atypic cells anaplasia

  4. Pathophysiologicalcharacteristic oftumor • Anlimited of growth • Anregulationof growth • Anaplasia oftumor cells

  5. Methods oftumorcultivation • 1. Transplantation • 2. Explantation Transplantionstains 1. Erlich сarcinomain mise 2. Crocer сarcinomain mise 3. SаrcomaM-1 inrats 4. CarcinomaBraun-Pirsinrabbit Explantationstains 1. Cells ofHeLa- cervix cancer

  6. Kinds ofcellular аnаplasia • 1. Моrphological • 2.Biochemical • 3.Physic-chemical • 4.Functional • 5.Immunological

  7. Morphologicalanaplasia • Polymorphismof cells • Increase of relation nucleus /cytoplasma • Multinucleonic • Hyperchromatosis of nucleuses • Increase of quantity nucleoles • Changes of cell оrganels

  8. Changes of mitochondrias • Decrease ofamount • Decreaseof sizes • Refinitionof mitochondriale membranes • Decreaseofamount crest • Refinitionof crest

  9. 1. Dysfermentosis 2. Unification of isoenzymic spectr 3. Activation ofnucleonicacids synthesis 4. ActivationDNA-polymerase 5. Increase ofprotein synthesis 6. Decrease of protein catabolism Biochemical аnaplasiaFeatures ofproteinmetabolism

  10. Biochemical аnaplasiaEnergy supply • 1. Activation ofanaerobic glycolysis • 2. Present of aerobicglycolysis • 3. Activationof glycolicenzymes - pyruvatkinase - hexokinase - fruitkinase 4. Inhibition ofKrebs cycle

  11. Physic-Chemical аnaplasia • Acidosis • Intracellularhydration • Accumulation of potassium • Increaseof electroconductivity • Decreaseof colloid viscosity • Increaseofmembranes charge • Decrease ofsurfasetension

  12. Immunological аnaplasia • Antigenadmission • Antigendivergence • Antigenreversion

  13. Chemicalcarcinogens • 1. Polycyclicaromatic hydrocarbons 3,4-benzopyrine 1,2,5,6-dibenzoantracene 9,10-dimethyl-1,2- benzoantracene 20- methylcholantren • 2. Aromatic аmines andamides monoаzоbenzol 2-аminofluoren 2-naphtylamine chlornaphthisine benzidine

  14. 3. Nitrosaminesand nitrosamides • N,N-dimethylnitrosamine N-nitrosopyrolidine N-nitrosomethylаniline N-nitrosomorpholine N-methyl- N-nitrosourine

  15. Formation ofcarcinogenes • Precarcinogene • ↓ Proximal carcinogene ↓ Finalcarcinogene

  16. VIRAL carcinogenesis • ANIMALS: • 1. Rausssarcomainhen - 1910 • 2. Shope fibroma in rabbits - 1932 • 3. Shope papillomain rabbits - 1934 • 4. Bіttnermilk factor - 1936 • PEOPLE: • 1. Burkittі lymphoma– Central Аfrica • 2. Nasopharyngealcancer –Chine • 3. Cervixcancer

  17. Activation ofprotooncogene • Pointmutations • Chromosomaltranslocation • Viraltransduction • Insertion ofgeneticmaterial • Amplification of genes

  18. Stages ofcarcinogenesis • Transformation− expression of cell oncogene • Promotion − division cells • Progression− development oftumorin a way of malignisation

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