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### Integrating Thinking, Moving, and Feeling: Uncovering Common Mechanisms in Aging Disorders ###

Join us for the 4th Annual Bedside to Bench Conference, where we delve into the interconnectedness of cognitive, movement, and mood disorders in older adults. This interdisciplinary event focuses on presenting evidence of co-occurrence, exploring common causal pathways, and discussing implications for clinical practice. Key aims include identifying knowledge gaps and future research directions. Engage with leading experts, participate in topical discussions, and contribute to the ongoing dialogue on how clinical observations can fuel aging research. ###

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### Integrating Thinking, Moving, and Feeling: Uncovering Common Mechanisms in Aging Disorders ###

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  1. Thinking, Moving, Feeling Common underlying mechanisms? 4th Annual Bedside to Bench conference R13 AG028320 John A. Hartford Foundation American Geriatrics Society

  2. Special Thanks • Planning committee Lew Lipsitz Susan Nayfield Joe Verghese Mike Zigmond • AGS coordinator Christine Campanelli

  3. Welcome Travel Grant Awardees AGS and NIA have a special commitment to trainees and junior faculty

  4. The Bedside to Bench series • Knowledge flows in both directions: from bench to bedside and also from bedside to bench • Aging research can be fueled by clinical observations about important but understudied problems • Clinical and basic science investigators can work together

  5. Thinking Moving and Feeling • Disorders of cognition, movement and mood often coexist in older people • These aging problems are usually studied separately by investigators who do not interact

  6. Specific Aims 1. Present evidence for co-occurrence of disorders of cognition, movement and mood in the older adult. 2. Explore potential common causal pathways from multiple basic and clinical perspectives. 3. Propose methods to help discriminate common pathways from random co-occurrence and bi- or tri-directional secondary effects. 4. Discuss implications for clinical practice. 5. Identify knowledge gaps and future directions for multidisciplinary research.

  7. Agenda • Topical clusters • Brief discussion after each speaker • Topical discussion after each cluster • Moderators will keep us on schedule!!

  8. Conference Products • Major findings and recommendations presented at AGS May 2008 • Manuscript summarizing issues, findings and recommendations to be published in 2008 • Written report to NIA

  9. Breakout groups assignments will be posted in the morning Day 1: dinner GROUP #1 – Initiation Factors (Independence Ballroom) Moderator: Lipsitz Recorder: Verghese GROUP #2 – CNS Changes (Patriot Room I) Moderator: Zigmond Recorder: Studenski GROUP #3 - Methodological issues and techniques (Patriot Room II) Moderator: Wagster Recorder: Nayfield Day 2: lunch GROUP #1 – Neural Systems (Independence Ballroom – Front) Moderator: Verghese Recorder: Zigmond GROUP #2 – Circulatory Systems (Independence Ballroom – Back) Moderator: Lipsitz Recorder: Nayfield GROUP #3 – Metabolic, Inflammatory & Humeral Systems (Patriot Room I) Moderator: Studenski Recorder: Newman

  10. Group assignments • Questions for the work groups 1. Key Gaps 2. Barriers & Opportunities 3. Methodological Work 4. Research Priorities • Reports Moderator and reporter create a power point presentation and make a 10 minute report to the conference as a whole

  11. Thank you for joining us Have fun!

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