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Advancing Childhood Cancer Treatment: TARGET Initiative Research Strategies

The TARGET Initiative focuses on understanding and utilizing genetic alterations in childhood cancers, including ALL and Neuroblastoma, to improve therapeutic approaches. By leveraging high-throughput genomic and transcriptomic profiling, gene resequencing, and functional validation, researchers aim to identify consistent alterations that can reveal potential therapeutic targets. Led by experts like Dr. Stephen Hunger and Dr. John Maris, this initiative fosters collaboration across clinical and research domains to develop more effective treatment strategies for children battling cancer.

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Advancing Childhood Cancer Treatment: TARGET Initiative Research Strategies

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  1. http://target.cancer.gov

  2. Areas for TARGET Initiative Research Focus Underlying premise: Genes that are altered in expression, copy number, or LOH and mutation will highlight cellular pathways for therapeutic exploitation Approach: • High-throughput array-based technologies to comprehensively characterize genomic and transcriptomic profiles • Gene resequencing to identify genes that are consistently altered in specific childhood cancers • Functional validation to validate putative therapeutic targets

  3. Cancer TARGET Initiative Strategy for ALL and Neuroblastoma Projects Disease Expertise – COG Disease Committee Genomic Characterization Expertise Gene Sequencing Expertise Transcriptomic Characterization Expertise Clinical Specimens

  4. Speakers for the ALL and Neuroblastoma TARGET Teams • Stephen P. Hunger, MD (ALL TARGET) • Professor and Ergen Family Chair in Pediatric Cancer • Director, Center for Cancer and Blood Disorders • Chief, Pediatric Hematology/Oncology/BMT • University of Colorado Denver and The Children’s Hospital • Chair, COG ALL Committee • John M. Maris, MD (Neuroblastoma TARGET) • Giulio D'Angio Associate Professor of Pediatrics • Chief, Division of Oncology • Director, Center for Childhood Cancer Research • Children's Hospital of Philadelphia • University of Pennsylvania School of Medicine • Chair, COG Neuroblastoma Committee

  5. Identifying More Effective Treatments for Children with Cancer TARGET Discovery Programs Pediatric Preclinical Testing Phase 1 Clinical Trial (COG, NANT, PBTC, CCR) COG Definitive Clinical Trial

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