YORK UNIVERSITY Department of Biology Faculty of Science and Engineering Course outline Immunobiology (SC/BIOL 3120 3.0)

1. YORK UNIVERSITY Department of Biology Faculty of Science and Engineering Course outline Immunobiology (SC/BIOL 3120 3.0) W2011 Prerequisites: SC/BIOL2020 4.0; SC/BIOL2021 4.0

2. Welcome to BIOL3120! SC/BIOL3120 3.0 Prerequisites: SC/BIOL2020 4.0; SC/BIOL2021 4.0 Objectives: The course is designed to provide students with a sound, comprehensive understanding of the immune system, including the Biology and Chemistry of immune responses. Topics will include anatomy/development of the immune system, structure and function of antibodies, T cell receptors, antigen receptor diversity, cellular interactions, and immunological responses in disease such as Cancer.

3. Instructor: Dr. Michael Scheid Rm. 236 Farqharson Building Website: www.yorku.ca/mscheid E-mail: through WebCT only please Course timetable: Tuesdays 11:30 am – 1:00 pm SLH  F   Thursdays 11:30 am – 1:00pm CSE  A Office hours: Friday 9:30-11:00 am

4. TEXTBOOK: The Immune System, Third Edition. Garland Science Author: Peter Parham Required Available at the York University Bookstore Two copies are available at the Stacie Library reserve desk

5. COURSE Web Site: WebCT • A York WebCT account is required to access • online course material. • Information about WebCT at York can be found at: • www.yorku.ca/fsc/webct/student/quickstart.htm • • WebCT is the online resource for this course. • It will be used for private mail to the instructor or • to the TA, for accessing your grades, and for • other course-related resources. • • Midterm examination grades will be posted when • they become available. Please do not email the • instructor nor the TA asking when grades will be • posted. • • The Midterms will not be returned but will be available • for viewing during office hours.

6. STUDENT EVALUATION: There will be TWO Midterm exams, each worth 25% of your grade: Midterm 1 – February 3 Midterm 2 – March 10 Final Exam : 50% [Date to be announced by registrar. Cumulative] [If an evaluation is not completed, a “0%” grade will be earned for that evaluation] • Please note: • Exam questions will be derived from lectures, lecture material and the text book. • Midterm exams will be multiple choice and true/false. • Final exam will be a combination of multiple choice, short answer, and long answer questions.

7. Please note : There will be NO MAKE-UP of the midterm exams. For medical issues please have your physician fill out the Attending Physician Statement. This form is available from the Registrars website.

8. Academic Integrity: Senate Policy on Academic Dishonesty Students are expected to be familiar with and follow York University’s Policies regarding academic integrity. Please consult the website below for more details: http://www.yorku.ca/academicintegrity/students.htm

9. • ACADEMIC MISCONDUCT WILL NOT BE TOLERATED. • Cheating is the attempt to gain an improper advantage in an academic evaluation. Forms of cheating include: – Obtaining a copy of an examination before it is officially available or learning an examination question before it is officially available; – Copying another person’s answer to an examination question; – Consulting an unauthorized source during an examination; – Obtaining assistance by means of documentary, electronic or other aids which are not approved by the instructor; – Changing a score or a record of an examination result; – Submitting the work one has done for one class or project to a second class, or as a second project, without the prior informed consent of the relevant instructors; – Submitting work prepared in collaboration with another or other member(s) of a class, when collaborative work on a project has not been authorized by the instructor; – Submitting work prepared in whole or in part by another person and representing that work as one’s own; – Offering for sale essays or other assignments, in whole or in part, with the expectation that these works will be submitted by a student for appraisal; – Preparing work in whole or in part, with the expectation that this work will be submitted by a student for appraisal.

10. For Thursday please read: Chapter 1 Elements of the Immune System Chapter 2 Innate Immunity

11. Why do we study Immunology?

13. From the following article: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean-Pierre Hugot et al. Nature 411, 599-603(31 May 2001)

14. From the following article: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean-Pierre Hugot et al., Nature 411, 599-603(31 May 2001)

16. From the following article: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, et al., Nature 411, 603-606(31 May 2001)

17. From the following article: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, et al., Nature 411, 603-606(31 May 2001)