1. Patient Cohort Cardiac Disease Burden Abbreviations: CCS – Coronary calcium score NYHA – New York heart association heart failure classification ACS – Acute coronary syndrome at the time of BM harvest CAD – Coronary artery disease ASD – Atrial septal defect (patent foramen ovale) Supplemental Table 1

2. Patient Cohort Medical History Abbreviations: DM – Diabetes mellitus HTN – Hypertension FHx CAD – Family history of coronary artery disease Supplemental Table 2

3. Patient Cohort Medication Profile 11 Abbreviations: ASA – Aspirin ACE-1 – Angiotensin converting enzyme inhibitor ARB – Angiotensin receptor blockade Beta Block – Beta adrenergic receptor blockers Supplemental Table 3