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Pathology of the age of development

Pathology of the age of development. DISSCUSED PROBLEMS I. Subject of the pathology of the age of development II. Pediatric neoplasia (neoplasms of the age of development) (theory and interactive part) III. Diagnostic methodes used in pathomorphology

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Pathology of the age of development

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  1. Pathology of the age of development DISSCUSED PROBLEMS I. Subject of the pathology of the age of development II. Pediatric neoplasia (neoplasms of the age of development) (theory and interactive part) III. Diagnostic methodes used in pathomorphology (routine stains, immunohistochemistry, molecular biology) IV. Currently used classification systems (aims, utility, general rules) V. Summary – pathomorphology of the age of development

  2. Pathology of the age of development NEW TERMS • solid tumors • small round (blue) cell tumors (SRCTs) NEW DIAGNOSTIC METHODES • immunohistochemistry • molecular biology • microarray

  3. Pathology of the age of development INTERACTIVE PART (for notes) • Wilms’ tumor • neuroblastoma • rhabdomyosarcoma

  4. Pathology of the age of development NOTES:Acute Leukemias Symptom • no matured RBC • no matured WBC • no matured platelets

  5. Pathology of the age of development NOTES: immunohistochemistry • aim • utility • limitations

  6. Pathology of the age of development NOTES: molecular biology • aim • utility • limitations

  7. Pathology of the age of development NEW CLASSIFICATION SYSTEMS- UTILITY & RULES (for notes) • Rule No 1 • Rule No 2 • Rule No 3 • Rule No 4 5. Rule No 5

  8. Pathology of the age of development NEW CLASSIFICATION SYSTEMS- UTILITY & RULES (for notes) New informations: • SIOP • NWTS Differences in treatment rules (based on protocols for Wilms’ tumor)

  9. Pathology of the age of development INTERNATIONAL RMS CLASSIFICATION I. Favorable Prognosis • a. Botryoid type • b. Spindle-cell subtype II. Intermediate Prognosis • a. Embryonal RMS • b. Pleomorphic RMS III. Poor Prognosis • a.Alveolar RMS - including solidvariant • b. Undifferentiated

  10. Pathology of the age of development • THE REVISED SIOP WORKING CLASSIFICATION OF RENAL TUMORS OF CHILDHOOD (2001) (FOR PRE-TREATED CASES) • I. LOW RISK TUMORS • Mesoblastic nephroma • Cystic partially differentiated nephroblastoma • Completely necrotic nephroblastoma • II. INTERMEDIATE RISK TUMOURS • Nephroblastoma - epithelial type • Nephroblastoma - stromal type • Nephroblastoma - mixed type • Nephroblastoma - regressive type • Nephroblastoma - focal anaplasia NWTS • III. HIGH RISK TUMOURS • Nephroblastoma - blastemal type • Nephroblastoma - diffuse anaplasia • Clear cell sarcoma of the kidney • Rhabdoid tumor of the kidney

  11. Pathology of the age of development • THE REVISED SIOP WORKING CLASSIFICATION OF RENAL TUMORS OF CHILDHOOD (2001) (FOR PRIMARY NEPHRECTOMY CASES) • I. LOW RISK TUMORS • Mesoblastic nephroma • Cystic partially differentiated nephroblastoma • II. INTERMEDIATE RISK TUMOURS • Non-anaplastic nephroblastoma and its variants • Nephroblastoma - focal anaplasia • III. HIGH RISK TUMOURS • Nephroblastoma - diffuse anaplasia • Clear cell sarcoma of the kidney • Rhabdoid tumor of the kidney

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