1 / 22

Doc: So you understand about your potassium intake? Dialysis Patient:

Doc: So you understand about your potassium intake? Dialysis Patient: Yeah, if I eat too many bananas my heart stops!. N. a. Cortical Collecting Duct Principal Cell Regulated Potassium Secretion. Tubular Fluid. Na +. K +. K +. Interstitial Fluid. N. a.

gyan
Télécharger la présentation

Doc: So you understand about your potassium intake? Dialysis Patient:

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Doc: So you understand about your potassium intake? Dialysis Patient: Yeah, if I eat too many bananas my heart stops!

  2. N a Cortical Collecting Duct Principal Cell Regulated Potassium Secretion Tubular Fluid Na+ K+ K+ Interstitial Fluid

  3. N a Cortical Collecting Duct Intercalated Cell Regulated Potassium Reabsorption K+ ATP H+ ? K+ Interstitial Fluid

  4. Factors which Influence K Secretion • Dietary Potassium and Plasma Potassium • Aldosterone • Flow Rate of the Tubular Fluid • ADH • Acid-Base Balance

  5. Na+ K+ CCD Principal Cell K+ K+ N a 1 2 Potassium Secretion: Effects of Plasma K+ and Dietary K+ High K+ diet Potassium Secretion (mEq/day) Normal diet 3 4 5 6 7 8 PK(mEq/L)

  6. K+ Adenal Cortex Aldosterone + FEK

  7. -Vte Na+ Na+ Late Phase AR N N a a Early Aldosterone Increases Potassium Secretion Tubular Fluid K+ R A K+ Interstitial Fluid

  8. K+ Na+ Physiological Range K+ CCD Principal Cell K+ K+ N a Potassium Secretion: Effects of Tubular Fluid Flow Rate High K+ diet Normal diet Potassium Secretion (mEq/day) Low K+ diet 0 10 20 30 40 50 Distal Flow Rate(nl/min)

  9. Na+ ADH N a ADH Increases Apical Potassium Channels Tubular Fluid K+ Principal Cell K+ V2 Interstitial Fluid

  10. Na+ K+ CCD Principal Cell K+ K+ N a 1 2 Potassium Secretion: Acute pH Effects Alkalosis, pH 7.5 Normal, pH 7.4 Potassium Secretion (mEq/day) Acidosis, pH 7.2 3 4 5 6 7 8 PK(mEq/L)

  11. Loop Diuretics ECV Distal K delivery Distal Flow Aldo Distal K Secretion K Excretion

  12. N a 25y/o Male with Liddle Syndrome, a Familial “Salt-Sensitive” Hypertension At Dx: BP 170/110 , PNa 140 mEq/l, PK 2.5 mEq/l , Low Renin/Aldosterone Vte- Na+ Tubular Fluid R K+

More Related