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Variable Sarcoglycan Expression in Muscular Dystrophies: Lack of Correlation with Severity

This study examines the expression levels of δ- and γ-sarcoglycans in various muscular dystrophy forms, including Duchenne muscular dystrophy (DMD), dysferlinopathy, and caveolinopathy. Western blot analysis revealed diverse expression levels of sarcoglycans in patients across different diagnoses, with no evident correlation to genetic causes or clinical severity. Controls were utilized for comparative analysis. The right panel features standard curves for each protein assessed, highlighting the complexity of sarcoglycan involvement in muscular dystrophy pathologies.

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Variable Sarcoglycan Expression in Muscular Dystrophies: Lack of Correlation with Severity

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  1. Supplementary Figure 5. Changes in sarcoglycan expression do not correlate with genetic cause or disease severity in known forms of muscular dystrophy. Western blot analysis of - and -sarcoglycan expression in 2 Duchenne muscular dystrophy (DMD) patients (lanes 2, 3), 2 dysferlinopathy patients (Dysf; lanes 5, 6) and 2 caveolinopathy patients (Cav; lanes 8, 9) demonstrates variable levels of the sarcoglycans without a clear relationship with diagnosis or disease severity. Lanes 1, 4, 7 & 10 are age-matched controls (C). Right panel shows standard curves for each protein (Std Curve).

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