Sickle Cell Anemia A blood disorder Ray Rega, Ryan Molter, Ryan Kosciolek
What is it? • A blood disorder that causes red blood cells to: - Elongate -Clog arteries • Blood cells are shaped like “Sickles,” or a crescent shape
What is it? • Normal blood cells can survive up to 120 days • Sickled blood cells can only live 10 to 20 days, and the bone marrow can not make enough cells to keep up. • Anemia is a disease where the person has a lower number of red blood cells than normal. • Most common inherited blood disorder: • 70,000 to 80,000 Americans affected. • 1 in 500 African Americans affected. • 1 in 1000 Hispanic Americans affected.
Symptoms • Blood cells become stiff and sticky which causes unnecessary clotting. • Pain in any organ or joint. • More susceptible to other diseases. • Clotting causes serious infection, organ damage, and strokes.
Symptoms • Other symptoms include: • Shortness of breath • Dizziness • Headaches • Coldness in the hands and feet • Paler than normal skin or mucous membranes (the tissue that lines your nose, mouth, and other organs and body cavities) • Jaundice (a yellowish color of the skin or whites of the eyes) • Sometimes swelling of the hands and feet.
Treatments • No cure • Some treatments can help, such as Blood and Marrow stem cell transplants • Most people with this disease are living to their forties, fifties, and higher.
Genetics • Sickle Cell Anemia is inherited • Life long • From birth • Two genes for sickle Hemoglobin, one from each parent.
Genetics • If one parent gives a gene for sickle Hemoglobin, and the other gives a normal gene, then… • They have what is called Sickle Cell Trait • This is not the same as Sickle Cell Anemia. It means that the person caries one trait of the disease. • Sickle Cell Anemia is due to a mutation in the HBB gene, which causes the hemoglobin to become deformed. • Is a recessive trait.
Bibliography "Sickle Cell Anemia, What Is." National Heart, Lung and Blood Institute. US Department of Health and Human Services, Feb. 2011. Web. 01 June 2011. <http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.ht ml>. "Sickle Cell Disease - Genetics Home Reference." Genetics Home Reference - Your Guide to Understanding Genetic Conditions. National Library of Medicine, 30 May 2011. Web. 01 June 2011. <http://ghr.nlm.nih.gov/condition/sickle-cell-disease>.