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Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9

Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9. ARIC PCSK9 Loss-of-Function Mutations, LDL-C, and CHD Risk. PCSK9-Directed Therapies in Development. Effects of Evolocumab (AMG-145) on LDL-C Levels Phase 1b Study Design.

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Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9

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  1. Dallas Heart StudyLipid Characteristics of Blacks With Nonsense Mutations in PCSK9

  2. ARICPCSK9 Loss-of-Function Mutations, LDL-C, and CHD Risk

  3. PCSK9-Directed Therapies in Development

  4. Effects of Evolocumab (AMG-145) on LDL-C LevelsPhase 1b Study Design

  5. Evolocumab -- Phase 1bChange in LDL-C at 2- and 4-Week Dosing Intervals on Statin Therapy

  6. PCSK9 InhibitorsPhase 2

  7. MENDELEvolocumab Phase 2 Monotherapy in Patients With Hypercholesterolemia

  8. MENDELStudy Design

  9. MENDELEvolocumab Monotherapy for Hypercholesterolemia

  10. PCSK9 InhibitorsPhase 2

  11. Alirocumab (SAR236553) Add-on to Atorvastatin

  12. AlirocumabChange in LDL-C at 2- and 4-Week Dosing Intervals on Atorvastatin

  13. Alirocumab on Top of Atorvastatin in Primary Hypercholesterolemia

  14. LAPLACE-TIMI 57Evolocumab in Combination With Statin in Patients With Hypercholesterolemia

  15. LAPLACE-TIMI 57 Study Design

  16. LAPLACE-TIMI 57 Effect of Evolocumab on Percentage Change in LDL-C From Baseline

  17. Intravenous RN316 in Hypercholesterolemic Patients on High or Maximum-Dose Statin Therapy Phase 2 Studies

  18. Intravenous RN316 in Hypercholesterolemic Patients on High- or Maximum-Dose Statin Therapy Doses Studied

  19. Intravenous RN316 in Hypercholesterolemic Patients on High or Maximum-Dose Statin TherapyPooled Results

  20. PCSK9 InhibitorsPhase 2

  21. GAUSSPhase 2 Evolocumab in Statin-Intolerant Patients

  22. GAUSSEvolocumab in Statin Intolerance

  23. PCSK9 InhibitorsPhase 2

  24. Effect of Alirocumab on LDL-C in Heterozygous FH

  25. RUTHERFORDPhase 2 Evolocumab in Patients With Heterozygous FH

  26. RUTHERFORDEffect of Evolocumab on LDL-C in Heterozygous FH

  27. Phase 3 Trials

  28. OSLER Phase 3 Extension Study

  29. OSLEREffect of Evolocumab on LDL-C after 52 Weeks

  30. ODYSSEY OutcomesPhase 3 Post-ACS With Alirocumab

  31. References

  32. References (cont)

  33. References (cont)

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