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Alexandr Uciteli , Silvia Groß, Sergej Kireyev, Heinrich Herre

An Ontologically Founded Basic Architecture for Information Systems in Clinical and Epidemiological Research. Alexandr Uciteli , Silvia Groß, Sergej Kireyev, Heinrich Herre. Introduction. Various clinical and epidemiological study projects Large amounts of data to be collected in similar form

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Alexandr Uciteli , Silvia Groß, Sergej Kireyev, Heinrich Herre

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  1. An Ontologically Founded Basic Architecture for Information Systems in Clinical and Epidemiological Research Alexandr Uciteli, Silvia Groß, Sergej Kireyev, Heinrich Herre

  2. Introduction • Various clinical and epidemiological study projects • Large amounts of data to be collected in similar form • Significant expense for the specification of data collection • => The qualitatively high grade and proven data definitions (study items) are necessary

  3. ISO/IEC 11179: Purposes • Standard description of data • Common understanding of data across organizational elements and between organizations • Re-use and standardization of data over time, space, and applications • Harmonization and standardization of data within an organization and across organizations • Management of the components of data • Re-use of the components of data

  4. ISO/IEC 11179: Basic Elements

  5. Ontological Foundation of the ISO/IEC 11179 standard

  6. Categories in General Formal Ontology (GFO) Distinctive features of GFO • Ontology for categories • Different kinds of categories • Categories of higher order • Transitive categories

  7. Architecture of the MDR and the Metamodel

  8. Ontological analysis

  9. Ontological embedding of ISO standard in GFO (partial tree)

  10. Items and Phenotypes • The notion of phenotype is insufficiently established and founded • An ontological analysis of the notion of phenotype is needed • The relation between items and phenotypes must be investigated

  11. Implementation • Creating and managing of all fundamental concepts of the ISO standard • Some extensions of the standard were implemented • Graphical representation of the concepts • Simple concepts can be connected by suitable relations to complex ones

  12. Prototype (1)

  13. Prototype (2)

  14. Prototype (3)

  15. Prototype (4)

  16. Conclusion • The semantics of ISO standard is insufficiently developed. • => Methodology how to specify the semantics based on top-level ontology • => A bridge between the standard and the rigorous methods of formal ontology

  17. Promising open problems • Ontological analysis of the notions of complex concept and phenotype • Reasoning capabilities

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