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D anish A ging R esearch C enter

The Copenhagen Group 1st year evaluation meeting 18 – 19 May 2009 Hotel Marienlyst, Helsingor. D anish A ging R esearch C enter. VELUX FONDEN. Why do we age so differently?. - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc.

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D anish A ging R esearch C enter

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  1. The Copenhagen Group 1st year evaluation meeting 18 – 19 May 2009 Hotel Marienlyst, Helsingor Danish Aging Research Center VELUX FONDEN Why do we age so differently? - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc

  2. On top of the Velux donation to DARC: Two more grant donations Copenhagen Aging and Midlife Biobank (CAMB) – funded by the Velux Foundation Center for Healthy Aging – funded by the Nordea Denmark Foundation

  3. Copenhagen Aging and Midlife Biobank (CAMB) General purpose: To establish a midlife biobank with focus on biological, cognitive and social variables - in order to study aging processes over the entire life course

  4. The Copenhagen Aging and Midlife Biobank – to be established 2009-2011 The Danish Longitudinal Study on Work, Unemployment and Health (born 1949, 1959) Age 40/50 45/55 The Metropolit Study (born 1953) Age 0 12 18 51 The Copenhagen Perinatal Cohort (born 1959-61) 45 Age 0 1 - 6 20 34 Pregnancy/Birth Childhood/adulthood Midlife

  5. Copenhagen aging and midlife biobank (CAMB) Follow-up study 2009 – 11 including blood samples, questionnaire, physical and mental tests 20.000 will be invited, we expect/hope for 10.000 participants The data collection takes place at National Research Center for Working Conditions in Copenhagen And started up 20 April 2009

  6. Tidlige aldringsindikatorer Low grade inflammation Parodontal inflammation Cognitive problems Low muscle function Physical performance Fatigue

  7. Blood samples- CAMB IL-6 DNA-repair hsCRP Cholesterol TNF-alpha Blood sugar IL-15 Hemoglobin IL-18 Triglycerides HbA1c

  8. Clinical examination - CAMB Height Weight Percentage of bodyfat Blood pressure Periodontal examination (in a subpopulation) Lung function (spirometry)

  9. Physical tests - CAMB Functional ability (chair-rise test) Muscle strength (hand-grip strength, ventral and dorsal thorax) Muscle power Balance Reaction time VO2 max (in a sub-population)

  10. Cognitive function - CAMB I-S-T 2000 R (Intelligenz-Struktur-Test) Sentence completion Sequence of numbers Analogies

  11. Questionnaire CAMB Health Oral health Fatigue Mental function (anxiety, depression) Socio-economic factors Work ability Working life history Social relations Social capital Health behaviours Indoor climate

  12. Perspectives - CAMB CAMB provides an outstanding possibility to study the influences of factors early in life (childhood and adolescence) on early aging in midlife CAMB will form the basis for numerous future studies on the importance of biological, cognitive and environmental factors in midlife for premature aging in later life

  13. Center for Healthy Aging University of Copenhagen Main Principal Investigator: Dean Ulla Wewer 5 research programmes: Neurobiology (PI: Professor Martin Lauritzen) Skeletal muscle metabolism (Professor Michael Kjær) Life course perspective on ageing (Professor Kirsten Avlund) Society, culture and health care policy (Professor Allan Krasnik) Health promotion and user innovation (Ass. Professor Lene Otto) Funded by the Nordea Denmark Foundation

  14. Center for Healthy AgingTheme 3. Aging in a life course perspective Focus on Biological, physiological, cognitive and self-reported markers of early aging Influence of social, mental and health factors throughout the life course on early aging

  15. Center for Healthy AgingTheme 3. Research group Professor Kirsten Avlund (PI for the group) Professor Finn Diderichsen Ass. Professor Rikke Lund Ass. Professor Erik Lykke Mortensen Professor Merete Osler

  16. Center for Healthy AgingOrganisation 1. Managing Director - ?? 2. Executive committee Birgitte Nauntofte Vilhelm Bohr Michael Kjær Erik Lykke. Mortensen 3. Steering group the theme leaders

  17. Research group in Gerontology at Department of Social Medicine Growing focus on research in gerontology A growing number of senior researchers Ph.d.-students Pregraduate students Development of courses in Gerontology More visibility Media Chapters in text books

  18. DARC-projects Fatigue and aging Copenhagen and Odense Fatigue and aging Ph.d.-project – Anette Ekmann Copenhagen and Aarhus/ Vejle Fatigue and molecular biomarkers Post. Doc. Laila Bendix

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