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Addressing Key Gaps and Opportunities in Neural Health Research

This outline highlights critical knowledge gaps in understanding the biological changes in humans due to exercise and their potential as biomarkers. It emphasizes determinants of recovery, characteristics of effective exercise, and how to promote brain health, particularly in high-risk populations. The discussion also includes barriers to research, such as the need for more precise measurements and the influence of mood. It identifies opportunities for large clinical trials and the importance of ongoing professional education. Methodological needs and future research priorities are also defined.

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Addressing Key Gaps and Opportunities in Neural Health Research

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Presentation Transcript

  1. Group onNeural Issues

  2. Outline • Key gaps in knowledge • Barriers and opportunities • Methodological needs • Research priorities for the future

  3. 1. Key gaps in knowledge

  4. 1. Key gaps in knowledge • Biological changes with exercise in humans • Can these changes provide biomarkers • Determinants of rate of recovery • Characteristics of effective exercise • Gender, race, culture-dependent efficacy • How best to promote brain health • Education? Incentives? Penalties? • Special requirements for people at high risk • Education of legislators, policy makers

  5. 2. Barriers and opportunities a. Barriers

  6. 2. Barriers and opportunities a. Barriers • Finer distinctions • Measurements of deficits • Design of Rx • “Reverse translation:” Bedside to bench • Need to expand considerations of mood (depression is only one facet)

  7. 2. Barriers and opportunities b. Opportunities

  8. 2. Barriers and opportunities b. Opportunities • Large clinical trials • Data sets • Ongoing or planned • Professional meetings (provide education)

  9. 3. Methodological needs

  10. 3. Methodological needs • How to influence behavior? (and when?) • More precise Rx • Tracking compliance • Better scales to measure • Prediction of responders to given treatment • Can genomics help? • Personality traits • Impact

  11. 4. Research priorities

  12. 4. Research priorities • What is impact of interventions, combos • Neurobiological • Clinical • How large is the problem? • Personal and Societal • What are the risk factors? • Identification of biomarkers (risk, impact) • Make better use of ongoing trials • Why low compliance? • How to promote behavior for healthy brain?

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