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Dynamic Role of GRKs and β-arrestin in Rab-Mediated Cellular Recycling Pathways

This study explores the intricate relationships between G protein-coupled receptor kinases (GRKs), β-arrestins, and Rab proteins in cellular recycling mechanisms. We detail the differential roles of Rab4 in fast recycling and Rab11 in slow recycling, alongside processes occurring in the Golgi complex, early sorting endosomes, and lysosomes. The internalization and trafficking routes are mapped to understand how these molecular players interact within the cell, offering insights into their implications for cellular homeostasis and signaling.

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Dynamic Role of GRKs and β-arrestin in Rab-Mediated Cellular Recycling Pathways

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  1. Ligand P P P GRK 1 GRK 2 β-arrestine P P P P CCP P P β-arrestine β-arrestine Rab4 (fast) Recycling 3 4 Internalisation Rab11 (slow) Golgi complex Early /sorting endosome GASP Rab7 5 Endoplasmic reticulum Rab11 Late endosome Nucleus Lysosome

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