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Impact of Delayed hCG Administration on IVF Outcomes

This study investigates the effects of delaying human chorionic gonadotrophin (hCG) hormone administration in IVF cycles on clinical outcomes. Results show no negative impact on embryo quality or pregnancy outcomes when hCG administration is postponed. This approach may offer flexibility in cycle scheduling.

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Impact of Delayed hCG Administration on IVF Outcomes

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  1. Timing van pick up Zeerweinigliteratuur

  2. MP Rosen et al FertilSteril 2008 • Prospectief • 235 cycliwaarbij 2934 oocytes werdengecollecteerdbehorendetot 5 groepennaarfollikelgrootte • HCG trigger bij 2 follicles >= 18 mm

  3. Hum Fertil (Camb). 2012 Sep;15(3):134-9. doi: 10.3109/14647273.2012.712739. • Timing of human chorionic gonadotrophin (hCG) hormone administration in IVF protocols using GnRHantagonists: a randomized controlled trial. • Morley L, Tang T, Yasmin E, Hamzeh R, Rutherford AJ, Balen AH. • Author information • Abstract • This randomized controlled trial investigated whether delaying human chorionic gonadotrophin hormone (hCG) administration within an IVF cycle impacts upon clinical outcomes. Participants included 125 women undergoing IVF/ICSI cycles at Leeds Centre for Reproductive Medicine. Subjects were aged 20-36 years, body mass index (BMI) 20-30 kg/m(2) with a normal FSH level (<8 IU/l). Administration of hCG took place 35-36 h prior to oocyteretrieval when there were ≥3 follicles ≥17 mm in diameter (Group A), delayed by 1 day (Group B) or 2 days (Group C). Outcomes included the number of oocytes retrieved per cycle, fertilization rate and live birth rate. On the day of oocyte retrieval, women in Groups B and C had significantly more mature follicles than Group A, although the number of oocytes retrieved did not differ (median = 12 in each group). Fertilization rates and embryo quality were comparable between groups. Pregnancies and live births per cycle were higher in Groups B and C (A = 30.8%, B = 54.1%, C = 38.7%; A = 17.9%, B = 27.0%, C = 25.8%), but did not reach statistical significance. Delaying hCG administration had no significant negative impact upon morphological quality of embryos, availability of surplus embryos for freezing or pregnancy outcomes. Postponing hCG may enable increased flexibility of cycle scheduling to avoid weekend procedures. • Comment in

  4. Miller et al in Obs&Gyn 1996 • Retrospectief • 50 pt voor en 50 na eenverandering van protocol • HCG leadingfollicle 17mm  20mm • Lang schema met agonisten • No significantdifference in pregnancy rate (23% vs 36%)

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