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Optimized Multidisciplinary Care Teams Enhance Antiretroviral Therapy Adherence --What We Know

HIVI. HIV Initiative of Kaiser Permanente and Care Management Institute. Optimized Multidisciplinary Care Teams Enhance Antiretroviral Therapy Adherence --What We Know. Michael Horberg, MD MAS FACP Director, HIV/AIDS Kaiser Permanente

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Optimized Multidisciplinary Care Teams Enhance Antiretroviral Therapy Adherence --What We Know

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  1. HIVI HIV Initiative of Kaiser Permanente and Care Management Institute Optimized Multidisciplinary Care Teams Enhance Antiretroviral Therapy Adherence --What We Know Michael Horberg, MD MAS FACP Director, HIV/AIDS Kaiser Permanente Executive Director Research, Mid-Atlantic Permanente Medical Group Clinical Lead, HIV/AIDS, Care Management Institute Vice-Chair, HIV Medicine Association

  2. Why The Care Team as Necessary? • Doctors don’t always discuss adherence with the patient or don’t emphasize it enough • Nachega, IAPAC/NIMH 2011; Golin, JGIM, 2004 • Patient treatment adherence is not static over time • Leading to changes in viral control over time (Mugavero, IAPAC/NIMH 2011) • Care necessities evolve over time • drug-drug interactions, co-morbidities do too • These impact adherence also • Structural issues can impact adherence • Including transportation, ease of refills Slide 2

  3. HIV Demographics—for purposes of reference *--Varies significantly by state KP and GHC operate in 9 states plus DC. KP HIV population rising annually; VA remains steady. Sources: CDC, KFF, VA, KP Slide 3

  4. KP Non-NQF HIV Quality Measures

  5. Our Non-NQF HIV Quality Measures Care coordination key here. Many person effort necessary—not just the physician!

  6. Our NQF/NCQA HIV Quality Performance Many team efforts here also. Outcomes are a team effort.

  7. (Re-)New Interest in “Medical Home” Emphasis on integrated, multi-disciplinary care (MDCT) HIV Specialist (ID or primary care) as “specialty leader” Case manager and care management Can be physically in one place or connected by technology Linkage to inpatient and outpatient care, lab, pharmacy services, consults Has been an element in HIV care Essentially, how KP practices HIV medicine Ryan White C clinics, VA also Not much research Some research but pre-combination ART(Le, 1998, Sherer, 2002) HIV specialist improved outcomes(Kitahata 2000, Delgado 2003) HIV clinical pharmacist(Horberg 2007) Slide 7

  8. Multidisciplinary Care Team Components (1) Potential Components: • NOTE: Need for local considerations always • HIV Specialist • Can be Infectious Disease Specialist • Or Primary Care with extended experience with HIV Care • Care Coordination • Often an RN, but not necessarily • Consider PA, clinical pharmacist, other • HIV Clinical Pharmacist • Nurse Case Manager Slide 8

  9. Multidisciplinary Care Team Components (2) • Social Work • Benefits Coordination • Access to outside services • ?Housing • ?Legal • Health Educator • Nutrition Service • Transportation Specialist • Identified Specialists in other disciplines • Oncology • Gastroenterology • Mental Health Slide 9

  10. IF antiretroviral naïve: ↑ panel size has modest effect on adherence and odds BLQ at 12 month Years of provider experience or specialty no association Significant association with ARV class (NNRTI) and year started greatest impact IF antiretroviral experienced: ↑ years provider experience associated with ↑ adherence and odds BLQ No association with panel size or specialty Significant association with older age, Caucasian, MSM, initiation after 2000 KP: Provider Experience and Outcomes Observational cohort data Horberg, Hurley, Towner, Allerton, Tang, Catz, Silverberg, Quesenberry, IDSA Abstract 1131, 2010; IAS Abstract MOPE464, 2011 Slide 10

  11. Clinical Pharmacists: Roles • Can have many roles • Adherence and adverse effect counseling • Manage adverse effects and drug-drug interactions • Ombudsman with dispense pharmacies • Research staff • Potentially case management • Physicians average 13 minutes entire course of a patient’s care discussing adherence while pharmacists spend 0.5-1.5 hours per visit discussing adherence • Older data, need to update • And this was adherence to antiretroviral medications only Golin, JGIM, 2004; Geletko, Am J Hlth Sys Pharm, 2002; Rathbun, Clin Ther, 2005

  12. HIV Clinical Pharmacists Study Horberg, Hurley, Silverberg, Quesenberry, Kinsman, JAIDS, 2007; 44:531-539 • 3538 patients evaluated—1571 antiretroviral naïve and 1967 experienced patients Adherence Results (multivariate analysis, p value): *--1st value is 0-50 patients; 2nd value is 51+ patients

  13. HIV Clinical Pharmacists Study(2) Utilization Results: *--1st value is 0-50 patients; 2nd value is 51+ patients Slide 13

  14. HIV Multidisciplinary Care Team Study (1) • Research Question: • What components of the HIV MDCT in combination are associated with the greatest increases in adherence? • Retrospective analysis of HIV+ patients in KP California (11,411) initiating a new ART regimen from 1996-2006. • ARV Naïve: 7,597 patients • ARV Experienced: 3,814 patients • Measured 12 month adherence to ART regimen using pharmacy dispense/refill records Horberg, Hurley, Towner, Allerton, Tang, Catz, Silverberg, Quesenberry, Treatment Adherence Conference, 2011

  15. Primary Predictor—Exposure to MDCT component by medical center (26): HIV Specialist (y/n) Nurse Case Manager Non-Nurse Care Coordinator Clinical Pharmacist Social Work/Benefits Counselor Dietician Mental Health Other Predictor Variables Age Gender Race/Ethnicity (White, Black, Latino, Other) HIV Risk (MSM, IDU, Heterosexual) HCV+ ART Regimen Class ARV Experienced Year this ART regimen was initiated (temporal trend) Medical Center (cluster variable) Provider (cluster variable) HIV Multidisciplinary Care Team Study (2) Slide 15

  16. HIV Multidisciplinary Care Team Study (3) • Classification and regression tree approach (recursive partitioning) to ascertain potential MDCT compositions associated with maximal mean ART adherence (CART Pro 6.0®, Salford Systems, San Diego, CA) • From above, potential combinations tested in adjusted* mixed linear regression to determine which associated with maximal ART adherence *--Clustering by medical center, provider, patient. Adjusted for ART experience, age, gender, race/ethnicity, HIV risk, HCV+, ART regimen class, temporal trend

  17. HIV MDCT Study (4): Recursive Partitioning First branch is clinical pharmacist. * p < 0.05 Multiple team combinations possible with significant effect.

  18. HIV MDCT Study (5): Teams Determined from RPMDCT below not significantly different between them Slide 18

  19. This Can Be Applied to Other Outcomes– Odds Maximal Viral Control Horberg, Hurley, Towner, Allerton, Tang, Catz, Silverberg, Quesenberry, IAS Abstract MOPE422, 2011 RX + CC RNCCM + SWBC CC only p<0.05 RNCCM only RX + MH Ref. RX=clinical pharmacist RNCCCM=nurse case manager CC=non-RN case coordinator SWBC=social work/benefits counselor MH=mental health worker Reference group is HIV specialist only RX + SWBC RX only p<0.05

  20. This Can Be Applied to Other Outcomes– Odds Maximal Viral Control First branch is clinical pharmacist. RX + CC RNCCM + SWBC CC only p<0.05 RNCCM only RX + MH Ref. RX=clinical pharmacist RNCCCM=nurse case manager CC=non-RN case coordinator SWBC=social work/benefits counselor MH=mental health worker Reference group is HIV specialist only RX + SWBC RX only p<0.05 Different results when stratified by ARV status.

  21. Discussion of MDCT Study Results • First study to consider all elements of HIV MDCT interactively • Clinical pharmacist is significantly associated with adherence improvement • Confirms prior study • Multiple combinations (5) are associated with significantly improved adherence • Compared to HIV specialist only • Likely some confounding by indication Slide 21

  22. Next Research Questions/Steps • Test MDCT optimized teams in prospective study • Also in different healthcare systems • Do these teams also improve other outcomes? • Accessing Care • Retention in Care • Mortality • Who are the key personnel for linkage to care? • Especially in non-integrated care systems • What services are not addressed by these teams? Slide 22

  23. Thank you! The great work continues. (Paraphrased from Angels in America)

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