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Understanding Skeletal Problems: Impact, Risks, and Need for Better Diagnostics

Skeletal diseases significantly decrease bone mass and quality, leading to millions of fractures annually and costing billions in treatment. The mortality rate can reach 25% within a year for older adults suffering hip fractures due to associated complications. Astonishingly, a 50-year-old Caucasian woman has a higher risk of dying from a fracture than from breast cancer. Although new therapies are emerging, they often come with severe side effects. Thus, there is an urgent demand for reliable, non-invasive diagnostic tools to assess bone health and inform therapeutic approaches effectively.

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Understanding Skeletal Problems: Impact, Risks, and Need for Better Diagnostics

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Presentation Transcript

  1. Why Study Skeletal Problems • Skeletal disease reduce the mass and quality of bone • They cause millions of fractures/year and costs tens of billions of dollars in therapy and rehabilitation • A 25% mortality rate within a year in older subjects who experience a hip fracture due to secondary ailments • A 50-year old Caucasian female has a higher chance of dying due to a fracture than due to breast cancer! • Although many new therapies have been developed, they often have serious side effects • Require reliable, non-invasive diagnostic tools to determine the need for and duration of therapy

  2. Structure of Bone

  3. Damage to Bone

  4. Vibrational Assessment

  5. How to do Physics I

  6. How to do Physics II

  7. How to do Physics III

  8. Modeling

  9. Computations

  10. Figure 5: Dynamic analysis of bone samples at various stages of bone loss indicated by amount of BMD. Experiments

  11. Summary

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