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TROMBOTIK MIKROANJIYOPATIK HASTALIKLAR; TTP ve H S

TROMBOTIK MIKROANJIYOPATIK HASTALIKLAR. Trombotik trombositopenik purpura (TTP) Hemolitik remik sendromGebelikle iliskili olanlar:- Preeklampsi-eklampsi- HELLP sendromu- Yaygin damar ii pihtilasma. TROMBOTIK TROMBOSITOPENIK PURPURA (TTP). ? Ilk defa 1924 yilinda Moskowitz tarafindan tarifl

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TROMBOTIK MIKROANJIYOPATIK HASTALIKLAR; TTP ve H S

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    1. TROMBOTIK MIKROANJIYOPATIK HASTALIKLAR; TTP ve HS Dr. Mehmet YILMAZ Gazaintep niversitesi Tip Fakltesi, Hematoloji Bilim Dali

    2. TROMBOTIK MIKROANJIYOPATIK HASTALIKLAR Trombotik trombositopenik purpura (TTP) Hemolitik remik sendrom Gebelikle iliskili olanlar: - Preeklampsi-eklampsi - HELLP sendromu - Yaygin damar ii pihtilasma

    3. TROMBOTIK TROMBOSITOPENIK PURPURA (TTP) ? Ilk defa 1924 yilinda Moskowitz tarafindan tariflenmistir. ? Insidansi 3-7/1.000.000 ? Klasik besli bulgu: - Mikroanjiyopatik hemolitik anemi - Trombositopeni - Nrolojik bulgular - Bbrek yetmezligi - Ates.

    4. TTP, PATOGENEZ ? VWF-cleaving protease (ADAMTS13) aktivitesi eksik. ? Plazmada ultra-large von Willebrand Faktr (ULVWF) multimerleri. Sonu: Trombositlerin artmis aktivasyonu ? mikrovaskler trombozlar.

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