Yanhuai Liu, President Beijing East Linden

1. World Traditional MedicinePatent Database Yanhuai Liu, President Beijing East Linden

2. Values of TCM • Developed and refined over thousands of years by the Chinese people for use in the prevention and treatment of disease, traditional Chinese medicine (TCM) is one of mankind’s greatest treasures. Inner Canon of Huangdi

3. World Traditional Medicine Patent Database World traditional medicine patent database (WTM) produced by East Linden is the world’s first and only traditional medicine patent database with integration of multinational patent resources.

4. Content Over 180K basic patents in traditional /natural medicine field（over 500K patent family members） are included. Countries & Organizations CN (TW included)，US，JP，KR，FR，DE，DD， SU，RU，GB，CA，AU，IE, NZ, IN, PH, SG, ZA, IL, NH, EP，WO Time Scope US : 1985 to present CN: 1985 to present Others: 1985 to 2008 Database Coverage

5. Bibliographic information Enhanced title, abstract, IPC Chemical structures Indexed terms and codes Therapeutic effects Formulas Patent citations Patent families Patent specifications Multilingual search (e.g. English, Latin and Chinese) Indexed terms search Natural medicine search Chemical structures search Formula and formula similarity search Synonym extension search Statistics analysis Contents & Main Features

6. WTMPD Scheme Search Options Patent Full-Text Compound Registration File Accompanying Diagram English Name English Synonym Chinese Name Chinese Synonym Chinese Systemic Name Chinese Pinyin Chemical Substance CN AP/PN Chemical Structure Searching Formula File Active Ingredient File TM Registration No. (CN) AP CAS Registration No. ( RN) Therapeutic Classification Specific Structure Search Substructure Search Patent Bibliographic Database Chemical Structure Chinese Standard Name Chinese Synonym Chinese Standard Name Chinese Synonym Latin Drug Name English Name Chinese Pinyin Latin Plant/Mineral name TM Registration No. WTM Registration File Uses/Effects Subject Terms Drug Classification Bibliographic Information

7. Auxiliary Files • Natural Medicine File • Collect all natural medicine existed in patent documents. More than 13000records are included • Unique code system provides Traditional Medicine Classification (TMC) for TCM. • Compound Registry File • Collect all active chemical components existed in patent documents. More than 14000 chemical components are included • Formula Information File • Synonym Dictionary

8. A Record of TCM Unique Code System

9. World Traditional MedicineRegistration File • World Traditional Medicine Registration File is designed to collect the natural medicine information all over the world. • On the basis of WTM registry file, more than 13,000 medicinal plants and 8,600 source plants are included in the file.

10. Indexed Term (IT)/ IT Code (ITC) • According to the character of natural medicine patent, the patent was classified in eight invention subjects with indexed term code.

11. Quick Search Search “hypertension” in all the fields Search History List

12. Quick Search Result Search “hypertension” and the synonyms in all the fields

13. Extension Search Result Set up field Check detailed patent information by clicking the patent number

14. A Sample Record Full-text link

15. CN Patent US Patent JP Patent PCT Patent KR Patent Full Text Patent Record

16. Advanced Search Check field code Search for TCM containing “Chinese Angelica” used in alopecia treatment Click expansion search

17. Advanced Search Result 276 search results

18. Refine Search Secondary search entry Refining search result by keying capsule in the abstract field

19. IPC Search Search for IPC related to “materials from plants”

20. Formula Logic Search Specifying number of components contained in target formulas Boolean search entry Specifying therapeutic effect

21. Formula Similarity Search Specifying number of formula components Inputting TCM formula components Narrowing the search result by formula size limitation Setting frequently used TM name list

22. TCM Name List

23. Natural Medicine Search Inputting Drug Name English Name and Synonyms Registry Number Latin Drug Name Latin Plant &Mineral Name Family Name

24. Chemical Structure Search Drawing a molecular structure in the panel Search for the exact chemical structure

25. Chemical Structure Search Result Click to show the original image of chemical structure

26. Sub-structure Search Drawing a molecular structure in the panel Search chemical structures with this substructure

27. Sub-structure Search Result 68 hits for substructure search Click to show the original image of chemical structure

28. Synonyms System Search for synonyms of NIDDM

29. Synonym Search Search for synonyms of NIDDM Add user-defined synonym

30. Statistic Analysis Select search query for statistics Select the type for statistics

31. Statistic Analysis

32. User Folder Adding patents into my patent folder

33. WTM Patent Database has been used by patent examiners ofSIPO of China as a major prior art database for pharmaceutical field. Workshops of WTMPD in SIPO of China

34. Usages of This Database • Prior art search • Pharmaceutical research • Infringement search • Freedom to operate • R & D

35. WTMPD Usage Examples • The database has been used heavily by examiners at SIPO for prior art search. • In 2009, by using our two databases - WTM patent database, TCM compound registry file and Shanghai TCM non-patent literature database , combining modern structure –biology technology and drug design technology, a research group has found a new way to design a new TCM recipe that may prevent and treat H1N1 virus infection.

36. Thank you for your time and attention! Liu Yanhuai East Linden, Inc. Tel: 86-10-82074090 Fax:86-10-82074090 Cell: 86-13621196207 Email: lyh@eastlinden.com