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1 University of Alberta, 2 Makerere University, 3 Kabarole Health Department

QUALITY OF LIFE OF HIV PATIENTS TWO YEARS INTO TREATMENT IN A COMMUNITY-BASED ANTIRETROVIRAL THERAPY PROGRAM IN WESTERN UGANDA. 1 University of Alberta, 2 Makerere University, 3 Kabarole Health Department .

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1 University of Alberta, 2 Makerere University, 3 Kabarole Health Department

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  1. QUALITY OF LIFE OF HIV PATIENTS TWO YEARS INTO TREATMENT IN A COMMUNITY-BASED ANTIRETROVIRAL THERAPY PROGRAM IN WESTERN UGANDA 1University of Alberta, 2Makerere University, 3Kabarole Health Department Catherine Paulsen1, Arif Alibhai1, Walter Kipp1, L. Duncan Saunders1, Joseph Konde-Lule2, Gian S Jhangri1, Tom Rubaale3

  2. Kabarole District • Southwestern Uganda • Primarily subsistence farmers • Adult HIV Prevalence: • Uganda: 6.5% • Kabarole District: 11.6%

  3. CBART Program • Community-Based Antiretroviral Therapy (CBART) Program • Improve access to treatment • Clinical outcomes comparable to best practice hospital • Health related quality of life also increased after one year of treatment • The aim of this study was to extend the analyses of health related quality of life in CBART patients to the two-year period after the initiation of treatment.

  4. Methods • A Rutoorotranslated version of the MOS-HIV survey, adapted for Uganda, was administered at baseline, year one, and year two for 122 of 185 CBART patients • Changes in MOS-HIV Physical Health Summary (PHS) and Mental Health Summary (MHS) scores, as well as individual domain scores, were assessed over the two-year period. • Means were compared using paired t-tests, and p-values were adjusted using the Bonferroni correction.

  5. Changes in Mean PHS & MHS Mean Mental Health Summary Score

  6. Changes in MOS-HIV Domain Scores * Indicates a p-value < 0.05; ** Indicates a p-value <0.001

  7. Type of Change in PHS & MHS Score

  8. Future Directions • Linear mixed models will be used to better understand the variability in health related quality of life over the two year period

  9. Conclusions • Mean physical and mental health summary scores, and most domain scores increased between baseline and year one, and were stable between year one and year two. • However, the aggregate scores mask the fact that approximately only 50% of patients had clinically significant (≥5 units) increases in their PHS and MHS scores.

  10. Acknowledgements We would like to acknowledge the support of Leah Martin, Ashley Wynne, Yan Chen, and the many dedicated staff and research assistants in Fort Portal, Uganda. This study was funded by a Canadian Institutes for Health Research (CIHR) grant.

  11. References • KippW, Konde-Lule J, Saunders LD, Alibhai A, Houston S, Rubaale T, Senthilselvan A, Okech-Ojony J.(2012). Antiretroviral treatment for HIV in rural Uganda: two-year treatment outcomes of a prospective health centre/community-based and hospital-based cohort. PLoS One. 7(7):e40902. doi: 10.1371/journal.pone.0040902. Epub 2012 Jul 17. • Alibhai A, Martin LJ, Kipp W, Konde-Lule J, Saunders LD, Rubaale T, Houston S, Okech-Ojony J. (2010). Quality of life of HIV patients in a rural area of western Uganda: impact of a community-based antiretroviral treatment program. Current HIV Research. 8(5):370-378.

  12. Questions?

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