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Bradford Greaves

Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models. Bradford Greaves. Need. http://www.searo.who.int/en/Section1174/Section1199/Section1567/Section1823_8066.htm. The APP Processing.

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Bradford Greaves

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  1. Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves

  2. Need http://www.searo.who.int/en/Section1174/Section1199/Section1567/Section1823_8066.htm

  3. The APP Processing Resveratrol Promotes Clearance of Alzheimer’s Disease Amyloid- Peptides, Marambaud 2005 Modified from Laurén et al., Nature (2009) Senile Plaques Figure 1 The β amyloid peptide can act as a modular aggregation domain, Link 2008

  4. Alzheimer’s Disease cont. http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf

  5. Oxidative Damage http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf

  6. Purpose To preventatively and therapeutically treat Alzheimer’s Disease with resveratrol using CL2006 and CL4176 C. elegan models

  7. Hypothesis Alternate Hypothesis: Both preventive and therapeutic treatment of resveratrol on CL2006 will lead to a decrease in amyloid beta production and for CL4176 there will be a delay of the onset of paralysis. Null Hypothesis: There will be no change in amyloid beta production nor paralysis with the addition of resveratrol.

  8. Resveratrol’s Coloration With Alzheimer’s Disease http://www.chiro.org/nutrition/ABSTRACTS/Resveratrol_in_Prevention_and_Treatment.pdf

  9. Soy isoflavoneglycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditiselegans, Gutierrez-Zepeda 2005 Transgenic C. elegans as a Model in Alzheimer’s Research, Wu 2005 Figure 2

  10. Do Ability • CL2006 and CL4176: Staining and Paralysis • Control food and Resveratrol available • Fluorescent Microscope at school • Prism not known (GFP)

  11. Bibliography Bundschuh, K. "The worm in humans." 11 Nov. 2008. Biotechnology and Life Sciences in Baden-Württemberg. 6 May 2009 <http://www.bio-pro.de/magazin/wissenschaft/archiv_2008/index.html?lang=en&artikelid=/artikel/00452/index.html>. Cheng, Louse. “Compound in Red Wine May Fight Alzeimer’s.” WebMD. 4 Nov. 2005. 15 Apr. 2009 <http://www.webmd.com/alzheimers/news/20051104/compound-in-red-wine-may-fight-alzheimer>. Duchen, Michael R. "Roles of Mitochondria in Health and Disease." Whereas some of the genes identified in the control of longevity appear to target mitochondria or at least to alter antioxidant defenses of the cell (Duchen, 2004. 2004. Diabetes. 7 May 2009 <http://diabetes.diabetesjournals.org/cgi/content/full/53/suppl_1/S96>. Halliwell, Barry, and John M.C. Gutteridge. Free Radicals in Biology and Medicine. 3rd ed. New York: Oxford UP, 2004. Lagouge, Marie, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott, Bernard Geny, Markku Laakso, Pere Puigserver, and Johan Auwerx. "Resveratrol Improves Mitochondrial Function and Protects Against Metabolic Disease by Activating SIRT1 and PGC-1a." Cell (2006). 20 May 2008. Lenker, David P. Professional Guide to Diseases. 8th ed. New York: Williams & Wilkins., 2005 Marambaud, Phillipe. Wine Compound May Help Cut Risk of Alzheimer’s Disease. 16 Nov. 2005. 24 Apr. 2009 <http://www.sciencedaily.com/releases/2008/06/080617165716.htm>. McKenzie, Maureen A. "Insulin Receptor-Like Protein." Patent Storm. 5 Oct. 1992. 18 Apr. 2008. O,Neill, Bill. "In Methuselah’s Mould." Feature 2 (2004): 0014-017. PLoS Biology. <http://www.culturagalega.org/imaxes/docs/plos_lonxevidade.pdf>. "Resveratrol Studies Suggest Broad Implications for SIRT1 Activation,in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease ( whether any of the Company's product ca...)." Bio-Medicine - latest biology and medical news/technology. 26 June 2007. 29 Apr. 2009 <http://www.bio-medicine.org/medicine-technology/Resveratrol-Studies-Suggest-Broad-Implications-for-SIRT1-Activation-0Ain-Neurodegenerative-Diseases-of-Aging-Such-as-Alzheimers-Disease-189-3/>. Rogers, Kara, ed. "Alzheimer's Disease." Encyclopædia Britannica. 15th ed. 2002. 306-07. Society for Neuroscience. "Grape Seed Extract May Reduce Cognitive Decline Associated With Alzheimer's Disease." ScienceDaily 18 June 2008. 29 April 2009 <http://www.sciencedaily.com /releases/2008/06/080617165716.htm>.

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