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This study explores the comparative acute and late toxicity levels of chemotherapy-enhanced radiation therapy versus altered fractionation in head and neck cancer treatment. By analyzing endpoints with higher toxicity, the research aims to delineate the safety profiles of both treatment approaches. The findings contribute to optimizing radiotherapy fractionation and concurrent chemotherapy, marking a significant advance in head and neck oncology. This work underscores the critical balance between treatment efficacy and minimizing adverse effects for patients undergoing these therapies.
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Table 4 Acute and late toxicity: endpoints with higher toxicity in the chemotherapy-enhanced radiation therapy-altered fractionation arm compared with the altered fractionation arm Bernier J (2005) Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology? Nat Clin Pract Oncol 2 305–314 10.1038/ncponc0201