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A Scheduling and Routing Algorithm for DMFS Ring Layouts with Bus-phase Addressing

This paper presents a novel scheduling and routing algorithm developed for digital microfluidic systems (DMFS) utilizing bus-phase addressing in ring layouts. It facilitates automated biochemical analyses through the precise manipulation of discrete nanoliter droplets on electrode arrays. Key benefits include reduced equipment size, minimal reagent usage, scalability, reconfigurability, and lower power consumption. The algorithm effectively coordinates droplet routing for independent and chain reactions, ensuring that chemical analyses conclude without unintended mixing, while also suggesting future optimizations and evaluations.

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A Scheduling and Routing Algorithm for DMFS Ring Layouts with Bus-phase Addressing

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  1. A Scheduling and Routing Algorithm for DMFS Ring Layouts with Bus-phase Addressing Megha Gupta Srinivas Akella

  2. Digital Microfluidic Systems • Used for automated biochemical analysis performed by repeatedly moving, mixing, and splitting discrete nanoliter-sized droplets on a planar array of electrodes. • Advantages:Reduced equipment size, smaller amounts of reagents, scalability, reconfigurability and power reduction. • Problem Statement: Given a ring layout with bus-phase addressing, and a set of reactions, generate an electrode activation schedule to coordinate droplet routing such that the chemical analysis is completed without any inadvertent mixing.

  3. Results • Designed an algorithm for two classes of reactions: independent and chain reactions. • Works for modified ring layouts with multiple inner rings and mixers. Future Work • Optimization of completion time. • Performance evaluation with different phase assignments to assist chip design. • Modifications to handle other bus-phase layouts, continuous mode reactions.

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