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CHAPTER 12 SEX-LINKED TRAITS

CHAPTER 12 SEX-LINKED TRAITS. Karyotype: a picture of chromosomes. Body Cells vs. Sex Cells. Autosomes: the first 22 homologous pairs of chromosomes. Autosomes are the same for both males and females. Sex cells : Determine sex of offspring. Is it Male or Female? Explain.

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CHAPTER 12 SEX-LINKED TRAITS

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  1. CHAPTER 12 SEX-LINKED TRAITS

  2. Karyotype: a picture of chromosomes.

  3. Body Cells vs. Sex Cells • Autosomes: the first 22 homologous pairs of chromosomes. • Autosomes are the same for both males and females. • Sex cells: Determine sex of offspring

  4. Is it Male or Female? Explain

  5. The sex chromosomes are the 23rd pair of chromosomes.  • XX =female • Sex chromosomes: determines the sex of the individual.

  6. XY=male

  7. Which parent determines the sex of an offspring? • DAD • Why? All moms have the genotype XX. When egg cells are made, they will all carry a single X chromosome.

  8. All dads have the genotype XY. When sperm cells are made, 50% will have an X chromosome and 50% will have a Y chromosome. • Therefore, males and females are born in roughly a 50:50 ratio.

  9. SEX-LINKED TRAITS • Those traits that are controlled by genes on the X or Y chromosomes. • NOTE: The Y chromosome is much smaller than the X chromosome and only contains a few genes. Most sex-linked traits are on the X chromosome.

  10. XH Xh XH Y In humans, hemophilia is a sex-linked trait.  Having hemophilia is recessive (Xh) to being normal (XH). The heterozygous female is called a carrier.  Cross a carrier female with a normal male. __ XHXh __  X  __ XHY ___ XH XH XH Xh male Xh Y XH Y

  11. XH Xh XH Y Results:Genotypic ratio:1 XHXH :1 XHXh : 1 XHY :1 Xh Y Phenotypic ratio:2 normal females: 1normal male: 1 male with hemophilia XH Xh Normal Female XH XH Normal Female Xh Y Male w/ hemophilia XH YNormal Male

  12. Now You Try • Cross a carrier female with a male with hemophilia. __ XHXh__  X  __ XhY ___

  13. XH Xh Xh Y Results:Genotypic ratio:1 XHXh :1 XhXh : 1 XHY :1 Xh Y Phenotypic ratio:1 normal female: 1 female w/ Hemopholia: 1normal male: 1 male with hemophilia Xh Xh Female w/ hemophilia XH Xh Normal Female Xh Y Male w/ hemophilia XH YNormal Male

  14. Genetic Sex-Linked Disorders Color Blindness Cause: x-linked recessive 1/10 males have, 1/100 females have. Why the difference? Individuals are unable to distinguish shades of red-green.

  15. Genetic Sex-Linked Disorders 2- Hemophilia A and B Recessive disorders that affect 1 of 5,000 males. These interfere with normal blood clotting and occur on the X chromosome.

  16. Using Fruit Flies to Study Genetics Thomas Hunt Morgan, 1908 Among normal red-eyed Drosophila he found a mutated white-eyed fly (male). Since it was a recessive gene that was expressed only in male flies, Morgan suggested that the chromosome was located on the X chromosome. Miniature winged mutation was transmitted on the same gene. These two characteristics did not always travel together. Morgan suggested that the chromosomes could swap parts and received the Nobel prize in 1934.

  17. Drosophila melanogaster

  18. X-linked Inheritance A situation where the genes that cause a disorder are located on the X chromosome. More male victims than female Hemophilia Color-blindness Duchenne muscular dystrophy

  19. Polygenic Inheritance • Traits that are influenced by several Genes. • Show many degrees of variation. Examples: • Height • Hair color • Skin Color • Eye Color

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