SARC Career Development Program

1. SARC Career Development Program Laurence Baker Jennifer Keene CTOS meeting London England November 14, 2008

2. SARC’s Goals • Engage expert sarcoma researchers and clinicians to improve outcome of patients with sarcoma • Collaboration of pediatric,medical, surgical, orthopaedic and radiation oncologists, pathologists, radiologists, medical geneticists, and molecular biologists • Progress against sarcomas depends on sustained, collegiate effort among these experts

3. Background • Grant from Roche to SARC • Awarded October 2007 • $2.5 million unrestricted grant • To promote sarcoma career development

4. How does SARC go about designing their own Career Development Award?? • Recipient / Eligibility characteristics • Terms of Award • Award Process

5. Laurence Baker* Jean Yves Blay* John Crowley Marie Debiec-Rychter Jonathan Fletcher Richard Gorlick Lee Helman* Steve Ritland Mark Thornton Matt Van de Rijn Jaap Verweij Jay Wunder SARC Career Development Award Committee * Co-Chair

6. Interviews: Young Investigator Awardees • More freedom • Protected time challenging • Changes in mentor • Pay off loans

7. Awards for Comparison • American Society of Hematology (ASH) • Leukemia & Lymphoma (L & L) • American Cancer Society (ACS) • American Society of Clinical Oncology (ASCO) • National Institute of Health (NIH) • K08 • K12 • K22 • K23

8. Physician 1+ years post final subspecialty training Full-time faculty appointment Completed postdoctoral/post-fellowship research Demonstrated ability for independent investigator-initiated clinical research Active member of ASCO Expect to spend 50% of time dedicated to Research Must have a mentor from their institution and institutional letter of support Applicants with existing career development awards (K23, K08, etc.) will not be considered for funding ASCO – CDA Criteria

9. Physician is 5-10 years post final subspecialty training Full-time faculty appointment Demonstrated ability for independent investigator-initiated clinical research Active member of ASCO Expect to spend 75% effort dedicated to research $450,000 over 3 years Raphael Rousseau MD, PhD Nanoparticle-based targeting Tumor neoangiogenesis to improve surgical resection in Osteosarcoma Scott Schuetze, MD PhD Study of sirolimus combined with cyclophosphamide in sarcoma ASCO – ACRA in Sarcoma

10. NCI K08 • Mentored Clinical Scientist Development Award the gold standard • Annually for 5 years • 75K per year plus fringe benefits • 30K research development expenses • 75% full-time professional effort to research career development

11. NIH K08 Awards for Sarcoma Research 2007, “Tumor Suppressors in Ewing’s Sarcoma”, Stephen L. Lessnick (University of Utah) 2007, “Tumor Antigen Presentation in Mice Developing Cancer”, Kevin F. Staveley-O’Carroll (Penn State Univ, Hershey Med Ctr) 2007, “An Animal Model for Kaposi’s Sarcoma”, Christopher H. Parsons (Med Univ of SC) 2007, “RAS-Mediated ERBB Signaling in Osteosarcoma”, Dennis P. Hughes (MDACC) 2007, “Secreted WNT Inhibitors in the Biology of Osteosarcoma”, Bang H. Hoang (U of C Irvine)

12. NCI K12 Paul Calabresi Award is a multi- and transdisciplinary institutional training award supporting the research career development of clinicians in clinical Oncology Awards (renewable) for up to $750,000 annually in direct costs or $1,050,000 annually (programs combining clinicians and PhDs) to institutions for up to five years

13. Mark R. Albertini, University of Wisconsin Robert C. Bast, Univ of TX, MDACC Irwin D. Bernstein, Fred Hutchinson CRC Bruce A. Chabner, Massachusetts General Ross C. Donehower, Johns Hopkins James S. Economou, U of CA Los Angeles Stephen G. Emerson, Penn Stanton L. Gerson, Case Western Reserve University Kenneth R. Hande, Vanderbilt University Lynn C. Hartmann, Mayo Clinic Rochester Herbert Kim Lyerly, Duke University Robert L. Martuza, Massachusetts General David G. Poplack, Baylor College of Medicine Gary K. Schwartz, MSKCC Kenneth S. Zuckerman, University of S. Florida Funded K12 Grants

14. 75K per year for salary and fringe benefits 30K for research development support 8% facilities and administrative costs (formerly called indirect costs) NCI K23 • Mentored Patient-Oriented Research Career Development Award • Support for up to 5 years of combined didactic and mentored research • Not renewable • 75% effort to research and research career development

15. NIH K23 Awards for Sarcoma Research • 2007,“Mechanism/Activity/Resistance/ Gleevec and GIST” • Jonathan Trent (MD Anderson) • 2007, “HSP as a Target for the Treatment of Childhood Cancer” • Rochelle Bagatell (University of Arizona)

16. Initial awards begin July 2009 Award $100,000/yr for 3 years Candidate within 5 years of completion of final training and must be physician Candidates must be from Europe, Canada or United States Candidate may not be supported by another career development award Maximum flexibility in funding Time commitment is important criteria If candidate awarded a research grant during term of CDA SARC CDA will continue with new research plan SARC Career Development Award

17. Institutional Commitment • Parent institutional commitment important • Required letter from mentor with detail of mentoring plan • Required letter from chairperson or equivalent detailing • role of individual on faculty • details regarding protected time • department/institutional resources provided • space, core support, other

18. SARC Grant Process • Submit 2 page letter and CV • Applications review/invite full application • Complete application using electronic formatwww.sarctrials.org • Timelines • Jan 1, 2009 • Letter of interest • Feb 1, 2009 • Invited full proposal • March 15, 2009 • Proposal due • May 1, 2009 • Notice of funding • July 1, 2009 • Funding begins

20. Jennifer Keene and Julia Baker Keene