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PATHOLOGY OF OSTEOARTHRITIS

ARTICULAR CARTILAGE. Avascular, alymphatic hyaline cartilageResist compressive forces by deforming but recover on removal of loadComposed of a. Chondrocytesb. Intercellular matrix (Collagen, Proteoglycans, and Water). ChondrocytesSynthesize matrix components (e.g. collagen and Pro

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PATHOLOGY OF OSTEOARTHRITIS

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    1. PATHOLOGY OF OSTEOARTHRITIS F. ALHILLI Department of Pathology, AGU

    2. ARTICULAR CARTILAGE Avascular, alymphatic hyaline cartilage Resist compressive forces by deforming but recover on removal of load Composed of a. Chondrocytes b. Intercellular matrix (Collagen, Proteoglycans, and Water)

    3. Chondrocytes Synthesize matrix components (e.g. collagen and Proteoglycans) Synthesize enzymes (e.g. collagenase) Capable of phagocytosis Collagen 85-95% Type I Collagen Type V and IX also present Other proteins present include chondronectin, anchorin Arrangements of collagen fibers Proteoglycans Link proteins, hyaluronic acid and glycosaminoglycans Bind large amount of water

    5. Osteoarthritris Chronic progressive degenerative destructive degradation of the articular cartilage of weight bearing joints leading to joint narrowing, subchondral bone thickening and eventually nonfunctioning painful joint The disease is primarily not an inflammatory lesion, but (reactive) infiltration by lymphocytes and plasma cells is present and minimal

    6. AETIOLOGY and PATHOGENESIS OF OSTEOARTHRITIS Primary Osteoarthritis Secondary Osteoarthritis

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