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Basics of Transfusion Therapy

Basics of Transfusion Therapy. Laura Cooling MD, MS Associate Medical Director Transfusion Medicine. Blood Transfusion Policies and Standard Practices. www.pathology.med.umich.edu Select: Clinical Resource “Blood Bank and Transfusion Services” Link on UMHS Clinical Homepage.

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Basics of Transfusion Therapy

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  1. Basics of Transfusion Therapy Laura Cooling MD, MS Associate Medical Director Transfusion Medicine

  2. Blood Transfusion Policiesand Standard Practices www.pathology.med.umich.edu Select: Clinical Resource “Blood Bank and Transfusion Services” Link on UMHS Clinical Homepage

  3. Practical Guide to Transfusion Medicine PRINT RESOURCE: By Marian Petrides, Gary Stack AABB Press

  4. THINK PINK PINK TOP TUBE FOR BLOOD BANK SPECIMENS ONLY

  5. Blood Collection • Most components results of single whole blood donations • 500 mL blood + anticoagulant • 20-30 min • Blood processed into components • packed RBC, FFP, platelets, cryo • Manufactured Components: IVIgG, albumin, factor concentrates, etc….

  6. Anticoagulants-Preservative • Anticoagulant: Sodium citrate • prevent coagulation through chelation Ca++ • Carbohydrate: Dextrose • RBC utilize glycolytic pathway • Buffer: Na Phosphate • Counter lactic acid acumulation • Adenine: Support ATP production • Mannitol: Stabilize RBC membrane

  7. ABO TYPES Fucose a1-2Galactose-R H-Antigen GalNAca1-3Gal-R Gala1-3Gal-R 2 2 Fuca1 Fuca1 A-Antigen B-Antigen

  8. DISTRIBUTION AND COMPATIBILITY OF ABO TYPES AND BLOOD COMPONENTS (holds true for solid organ transplant as well)

  9. % Donors Compatible/Component

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