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I. cAMP. I. R-SMAD. c-jun. R-SMAD. Smad4. . p300 /CBP. p300 /CBP. p300 /CBP. Phospho-Serine. Phospho-Threonine. TGF- b. IFN- g. TNF- a. TGF- b. PGE 2. IFN- g. II. II. cytoplasm. SMAD7. FKBP12. JNK. SARA. JAK1. R-SMAD. Smad4. Smurf1/2. PKA. R-SMAD. Smad4. CREB.

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  1. I cAMP I R-SMAD c-jun R-SMAD Smad4  p300 /CBP p300 /CBP p300 /CBP Phospho-Serine Phospho-Threonine TGF-b IFN-g TNF-a TGF-b PGE2 IFN-g II II cytoplasm SMAD7 FKBP12 JNK SARA JAK1 R-SMAD Smad4 Smurf1/2 PKA R-SMAD Smad4 CREB STAT1a Ski/SnoN SNIP nucleus R-SMAD Smad4 Gene expression Figure 1

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