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Where Angels Feared to Tread

????????????. Where Angels Feared to Tread. Roger Ashby Hunter-Fleming Ltd. Technology Transfer. Experience from both sides Hunter-Fleming, an example Working with universities. HUNTER FLEMING. PHARMACEUTICAL PIPELINE PROVIDERS.  Hunter-Fleming Ltd. Mission.

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Where Angels Feared to Tread

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  1. ???????????? Where Angels Feared to Tread Roger Ashby Hunter-Fleming Ltd

  2. Technology Transfer • Experience from both sides • Hunter-Fleming, an example • Working with universities

  3. HUNTER FLEMING PHARMACEUTICAL PIPELINE PROVIDERS  Hunter-Fleming Ltd

  4. Mission To be a leading, highly profitable, international company supplying novel breakthrough prescription medicines to global marketing companies, in areas of significant unmet medical needs. PATENT TO PATIENT  Hunter-Fleming Ltd

  5. The Market  Hunter-Fleming Ltd

  6. Management • Giles Vardy, Non Exec Chairman, Chairman of AIM Steering Group, former CEO of Greig Middleton, Chairman CQS Management, alternative asset management business • Dr Jim Murray, CEO: co-founder of Shire, 29 years in Pharma industry • Professor Ernst Wulfert, CSO: former Research Director UCB responsible for the development of three blockbuster drugs – Keppra, Zyrtec, enofibrate • Dr. John Fox, Managing Director: Head of Planning at Shire, 20 years in pharmacology & clinical research • Neil Hockaday, FD: COO HSBC Corporate Banking  Hunter-Fleming Ltd

  7. University Collaborations • Bristol • Belfast • Southampton • St Marianna Hospital, Medical School, Kawasaki • Loyola, Chicago • CNAM, Paris • Kyoto Pharmaceutical University, Japan • Tromso, Norway • Strathclyde/Glasgow  Hunter-Fleming Ltd

  8. Business Model VALUE C NDA, drug filing B “Innovations Break Point” A Basic Discovery COST Basic Research ACADEMIA Innovation HF Drug Development BIG PHARMA  Hunter-Fleming Ltd

  9. IntegratedTherapies anti-neurodegenerative drugs (brain inflammatory diseases)HF 0220 Neurosciences (neurodegenerative diseases, AD, PD, stroke, MS…) Immunology & Inflammation (RA, Type I diabetes, asthma, rhinitis, cancer..) Cardiovascular & Metabolic Disorders (CHD, MI, Diabetes…) Novel cytoprotective drugs brain, heart, kidney HF 0220 “follow-ups” Anti-diabetic HF 1020  Hunter-Fleming Ltd

  10. Portfolio  Hunter-Fleming Ltd

  11. WHY ? • Access to blue sky research • Access to intellectual property • Access to ongoing research output

  12. FACT • British Telecom research spend £30m pa • Bristol University, - • UCL, Imperial College, - £500m pa • Southampton University -

  13. ACADEMIA Solutions seeking applications

  14. INDUSTRY Paucity of innovative knowledge cf Pharma 50% all new medicines in-licensed

  15. KEY ISSUES • Point of contact • Executive authority • Ability to deliver – Willing scientists • - Secured IP • Continuity

  16. Deal Breakers • Valuation of IP and / or Know how • Limitation of management expertise

  17. Decision • Licence OR • Start up new company

  18. Hunter-Fleming • Mature management team • Proven track record • Understand university’s modus operandi • Enduring partnership • Virtual circle taking IP to market • Financial returns to all- University • - Research Staff • - H-F shareholders

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