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Molecular Interactions and Signaling Pathways Regulating Cancer Progression

Explore the intricate network of signaling pathways and molecular interactions involved in cancer progression. Uncover key targets and understand the dynamics behind cancer cell growth and survival.

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Molecular Interactions and Signaling Pathways Regulating Cancer Progression

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  1. MEK1/2 S217/221 ERK1/2T202/Y204 JAK2Y1007/1008 βCAT S33-37/T41 JAK1Y1022/1023 SMAD2S245/250 NFKBP65 S536 S6RPS240/244 S6RPS235/236 βCAT T41-S65 AMPKb1 s108 pHSP90a T5/7 AMPKa1 s485 Met1234/1235 TuberinY1571 IGF1R_Y1135 p90RSKS380 p38T180Y182 4EBP1T37/46 JNKT183/185 P70S6KS371 P70S6KT389 EGFRY1068 MTORS2448 SMAD2S465 CASP9D315 HH2AXS139 CASP3D175 CASP9D330 EGFRY1148 EGFRY1173 ERB2Y1248 ERB3Y1289 STAT3S727 STAT1Y701 PLCg1Y783 STAT5Y694 STAT3Y705 STAT2Y690 GSK3S21/9 IkBaS32-36 CHK1 S345 ALKY1604 Tubulin a/b CREBS133 PARPD214 MEK1S298 CABLY245 GSK3S279 CABLT735 PDK1S241 PTENS380 4EBP1S65 cRAFS259 ALKY1586 4EBP1T70 PLK1T210 BRAF445 FKHRS56 CDC2Y15 BADS112 ARAF299 AKTS473 ATRS428 ERaS118 CofilinS3 Crafs338 VEGFR2 WNT5ab Survivin IRS1612 SGKS78 cKIT703 P53S46 E-Cadh ckit719 CycD1 ErbB2 EGFR ALDH BCL2 TGFb P21 p27 MDA-MB-361 si-CNTR(1) MDA-MB-361 si-CNTR(2) MDA-MB-361 si-CNTR(3) MDA-MB-361 si-hMENA11a(1) MDA-MB-361 si-hMENA11a(2) MDA-MB-361 si-hMENA11a(3) MDA-MB-361 si-hMENA11a+NRG-1(1) MDA-MB-361 si-hMENA11a+NRG-1(2) MDA-MB-361 si-hMENA11a+NRG-1(3) MDA-MB-361 si-CNTR+NRG-1(1) MDA-MB-361 si-CNTR+NRG-1(2) MDA-MB-361 si-CNTR+NRG-1(3) PAK1 T423/PAK2 T402 Supplementary Figure 1

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